Although current anti-cancer protocols are reasonably effective, treatment-associated long-term side effects, induced by lack of specificity of the anti-cancer procedures, remain a challenging problem in pediatric oncology. TAT-RasGAP317-326 is a RasGAP-derived cell-permeable peptide that acts as a sensitizer to various anti-cancer treatments in adult tumor cells. In the present study, we asses...

Rational design concepts were used to prepare a novel porous benzimidazole-linked polymer (BILP-101) in a simple one-pot reaction. BILP-101 has exhibited ultra-microporosity (0.54 nm), very high CO2 uptake (∼1 mmol g(-1), 4 wt%, 0.15 bar/298 K) and exceptional CO2/N2 selectivity of 80 (298 K), which results in remarkable working capacity and regenerability for CO2 capture applications.

Skin is the outmost barrier that separates human body from external environment. In psoriasis, immune cells are resident and / or infiltrated into epidermis in order to form epidermal immunological microenvironment (EIME) constitute a complex interaction with keratinocytes, together nerve microbiota influence. Our results have shown psoriasis mainly mediated by specific inflammatory environment...

Dermatology is a broad specialty, and clinical trial resources are limited. We sought to describe current disease focus resource allocation. tabulated trials from 5 dermatology journals (JAMA Dermatology, BJD, JID, JAAD, JEADV) 2015-2019. Study characteristics, funding, were extracted. Results descriptive, associations with industry funding investigated logistic regression. 265 met inclusion cr...

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AMA Zalas K, Kuliczkowski W, Pachana J, Mycka R, Rakoczy B. Is ST-segment elevation myocardial infarction always a simple diagnosis?. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2023;19(3):298-300. doi:10.5114/aic.2023.131488. APA Zalas, K., Kuliczkowski, W., Pachana, J., Mycka, R., & Rakoczy, (2023). Interwencyjnej, 19(3), 298-300. https://doi.org/10.5114/aic.20...

BACKGROUND Suboptimal activation of T lymphocytes by melanoma cells is often due to the defective expression of class I major histocompatibility antigens (MHC-I) and costimulatory molecules. We have previously shown that geranylgeranyl transferase inhibition (done with GGTI-298) stimulates anti-melanoma immune response through MHC-I and costimulatory molecule expression in the B16F10 murine mod...