Background—Transforming growth factor-b2 (TGF-b2) is a member of a family of growth factors with the potential to modify multiple processes. Mice deficient in the TGF-b2 gene die around birth and show a variety of defects of different organs, including the heart. Methods and Results—We studied the hearts of TGF-b2–null mouse embryos from 11.5 to 18.5 days of gestation to analyze the types of de...

TiNi-based shape-memory alloys are known to exhibit a strain glass state under certain conditions, generally in the presence of high-density defects such as excess solute atoms or alloying elements, dislocations, and nanoprecipitates. In this paper, we report transition nanocrystalline ${\mathrm{Ti}}_{50}{\mathrm{Ni}}_{35}{\mathrm{Pt}}_{15}$ alloy. The is achieved by combined effect grain bound...

Abstract HOCN and HNCO abundance ratio in molecular gas can tell us the information of their formation mechanism. We performed high-sensitivity mapping observations HOCN, HNCO, HNC 18 O lines around Sagittarius B2 (Sgr B2) with IRAM 30 m telescope at 3 mm wavelength. 4 04 –3 03 are used to obtain HOCN. The is calculate optical depth . observed range from 0.4% 0.7% toward most positions, which a...

Kallikrein cleaves low molecular weight kininogen to generate vasoactive kinins, which bind to the kinin B2 receptor, triggering a host of biological effects. Kallikrein gene delivery has been shown previously to reduce ischemia/reperfusion-induced cerebral infarction. In this study, we tested the hypothesis that the kinin B2 receptor plays a protective role in ischemic brain injury using kinin...

Our previous studies have detailed a novel facilitative UT-B urea transporter isoform, bUT-B2. Despite the existence of mouse and human orthologs, the functional characteristics of UT-B2 remain undefined. In this report, we produced a stable MDCK cell line that expressed bUT-B2 protein and investigated the transepithelial urea flux across cultured cell monolayers. We observed a large basal urea...

BackgroundImmune checkpoint inhibitors (ICI) have become a new standard of treatment patients with advanced non-small cell lung cancer (aNSCLC), but 60% are resistant to the therapy. The aim this study was investigate prognostic value immunological markers in aNSCLC receiving anti-PD-1/PD-L1 antibody.MethodsThe included 2 groups: group 1- 45 ICI monotherapy and subsequent lines, 2- 30 first-lin...

The objective was to evaluate the fermentation profile, aerobic stability, chemical composition, and mineral content of silages mango combined with cocoa pod husk meal. A completely randomized design adopted, including four levels (65, 70, 75, 80%) five repetitions, totaling 20 experimental silos that were opened after 90 days sealing. Increasing in increased dry matter recovery, total carbohyd...