The reactivity and catalytic performance of 2-ethylpyrido[1,2-c][1,2,4]-triazol-3-ylidene 6 have been comprehensively investigated. The carbene 6 has shown unusual properties owing to the effect of the pyrido-annulation. While formohydrazide 8 and hydrazine 9 are obtained via the destruction of the triazole skeleton of the carbene, 3-((1Z,3E)-4-(1H-pyrrol-1-yl)buta-1,3-dienyl)-1-ethyl-1H-1,2,4-...

5-(1H-Indol-2-yl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione 1a and 4-(4-chlorophenyl)-5-(1H-indol-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 1b were galactosylated in the presence of NaHCO3 ethanol to produce S-galactosides 3,4, whereas, K2CO3 acetone they produced a mixture S- N-galactosides 3-6 with higher yield over respective N-galactosides. Improvement yields was by thermal migrati...

The title compound, C(2)H(4)N(3) (+)·[H(C(2)H(3)N(3))(2)](+)·2C(7)H(5)O(6)S(-)·2C(2)H(3)N(3), consists of two types of 1,2,4-triazole monocation, one protonated at the 2-site lying across a twofold axis and the other protonated at the 4-site with the H atom disordered over a center of symmetry, a 5-sulfosalicylate anion and a neutral 1,2,4-triazole mol-ecule. The component ions are linked into ...

A series of triazenes derived from 5-(4-aminophenyl)-2,4-dihydro–4-substituted-3H-1,2,4-triazole-3-thiones 1a-c, aminoglutethimide or para-aminobenzoic acid have been synthesized for in vitro anticancer properties against three cell lines. The selected compounds; 1,3-bis[4(4-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thioxo-5-yl)phenyl]-3H-triazene 2a, 1,3-bis[4(4-ethyl-2,4-dihydro-3H-1,2,4-triazol...

In the title N-Mannich bases, 3-(adamantan-1-yl)-4-(4-fluoro-phen-yl)-1-[(4-phenyl-piperazin-1-yl)meth-yl]-4,5-di-hydro-1H-1,2,4-triazole-5-thione (C29H34FN5S) (I), and 3-(adamantan-1-yl)-4-(4-fluoro-phen-yl)-1-{[4-(2-meth-oxyphen-yl)piperazin-1-yl]-meth-yl}-4,5-di-hydro-1H-1,2,4-triazole-5-thione (C30H36FN5OS) (II), fluoro-phenyl, adamantane and piperazine moieties are linked to a planar triaz...

The triazole core is one of the most imperative and well known heterocycles which composed nitrogen atom forms natural products with medicinal claims. Triazole moiety present as a principal structural component in drug categories such antimicrobial, anti-inflammatory, analgesic, antineoplastic, antimalarial, antiviral, antihypertensive, local anaesthetic, antianxiety, anti-Parkinson′s, antidepr...

The inhibition of Salmonella typhimurium by 1,2,4-triazole appears to be mediated through an effect on L-cysteine biosynthesis. O-Acetylserine sulfhydrylase A, the final enzyme in the L-cysteine biosynthetic pathway, was found to catalyze a reaction (triazolylase) between O-acetyl-L-serine and 1,2,4-triazole, giving 1,2,4-triazole-1-alanine as a product. In wild type S. typhimurium grown on 4 m...