Objective: Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric disorder affecting 5% of children. Methylphenidate (MPH) is a common medication for ADHD. Studies examining MPH’s effect on pediatric ADHD patients’ brain function using functional magnetic resonance imaging (fMRI) have not been compiled. The goals of this systematic review were to determine (1) which areas of the brain...

The prescribed use of methylphenidate in the treatment of attention deficit hyperactivity disorder (ADHD) is widespread. The intranasal and parenteral abuse of methylphenidate (Ritalin) among teenagers is becoming increasingly more common, and deaths have been reported. Newer medical treatment options of long-acting stimulants offer effective treatment with a lower risk of abuse potential. We d...

INTRODUCTION The research described here is a continuation of an ongoing project whose aim is the synthesis and characterization of derivatives of (±)-threo -methylphenidate (TMP; Ritalin) with potential in the treatment of cocaine (COC) abuse 1, 2, 3, 4, 5, 6, 7 . The reinforcing and stimulant effects of COC are thought to be due, at least in part, to the drug’s ability to block dopamine (DA) ...

The psychostimulants amphetamine and methylphenidate (MPD/Ritalin) are the drugs most often used to treat attention deficit hyperactivity disorder (ADHD). In addition, students of all ages take these drugs to improve academic performance but also abuse them for pleasurable enhancement. In addition, other psychostimulants such as 3,4-methylenedioxymethamphetamine (MDMA/ecstasy) are used/abused f...

OBJECTIVE The aim of this study was to compare the pharmacodynamics of a new multilayer-release (MLR) formulation methylphenidate (MPH; Biphentin) with immediate-release (IR) MPH (Ritalin) in a double-blind, cross-over, placebo-controlled study in patients with attention-deficit/hyperactivity disorder (ADHD). METHOD Patients were randomized to equivalent doses of MPH as MLR (once per day), IR...

We describe a case of pulmonary granulomatosis in a user who habitually injected methylphenidate (Ritalin) intravenously; symptomatic and objective improvement occurred with corticosteroid therapy. A scan of the lungs using radioactive 67gallium showed an increased concentration of 67gallium throughout both lungs. There was a reduction in abnormal accumulation of 67gallium, improvement in the a...

2&tag contentMain;contentBody. Accessed April 16, 2012 14. Talbot M. Can a daily pill really boost your brain power? 60 Minutes. http://www.guardian.co.uk/science/2009/sep/20/neuroenhancers-usbrain-power-drugs. Accessed April 16, 2012 15. Ritalin. http://www.evaluatepharma.com/Universal/View.aspx? type Entity&entityType Product&id 10818&lType mod Data&componentID 1002. Accessed April 16, 2012 1...

Information about injection drug users' lifestyles is necessary to develop effective harm reduction strategies. One way to gather this information is through needle exchange programs. In 1998, a convenience sample of 100 clients of Saskatoon's needle exchange service was interviewed about their injection and sexual practices. Ritalin and morphine were the most commonly injected drugs. Over half...