introduction: neurotrophins belong to growth factor family and their function is based on their receptors. they bind two types of receptors: p75 and tyrosine kinase. the motoneuron survival or death depends upon the neurotrophic factors. recent studies have demonstrated that axotomy in peripheral nerve induces apoptosis of motoneuron. deprenyl or selegiline is known as a drug with neuroprotecti...

The scientific review considers the mechanisms of action cytoplasmic microRNAs, namely miRNA-mediated silencing, which is caused during initiation and post-initiation period translation. To write article, information was searched using Scopus, Web Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, Cochrane Library, CyberLeninka databases. It known that silencing translation occurs...

several cell lines (18) of poorly differentiated rat ascites hepatomas which grown intraperitoneally were analyzed with respect to their mrna levels of gst-p and albumin. the expression of albumin was dramatically decreased and became undetectable in all of the examined hepatomas compared with normal rat liver. the gst-p mrna level in the hepatomas was correlated with their ability for formatio...

Introduction: Neurotrophins belong to growth factor family and their function is based on their receptors. They bind two types of receptors: p75 and tyrosine kinase. The motoneuron survival or death depends upon the neurotrophic factors. Recent studies have demonstrated that axotomy in peripheral nerve induces apoptosis of motoneuron. Deprenyl or Selegiline is known as a drug with neuroprote...

background: rfamide-related peptide-3 (rfrp-3) inhibits gonadotropin releasing hormone (gnrh) and luteinizing hormone (lh) secretion in rats. this study evaluates the effects of litter size and suckling intensity on rfrp mrna expression in the dorsomedial hypothalamic nucleus (dmh) of rats. materials and methods: a total of 32 pregnant and 4 non-lactating ovariectomized (control group) sprague-...