Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-regulated, cAMP-activated chloride channel located in the apical membrane of many epithelial secretory cells. Here we report cloning of a cAMP-activated epithelial basolateral chloride conductance regulator (EBCR) that appears to be a basolateral CFTR counterpart. This novel chloride channel or regulator shows 49% identity wit...

Main-chain polymers of chiral imidazolidinone were successfully synthesized by reaction of chiral imidazolidinone dimers with disulfonic acid. Chiral imidazolidinones were incorporated into the main-chain of the polymer by ionic bonding. These polymers could be used as polymeric chiral organocatalysts for asymmetric Diels-Alder reactions.

The direct CO2 electrochemical reduction on model platinum single crystal electrodes Pt(hkl) is studied in [C2mim(+)][NTf2(-)], a suitable room temperature ionic liquid (RTIL) medium due to its moderate viscosity, high CO2 solubility and conductivity. Single crystal electrodes represent the most convenient type of surface structured electrodes for studying the impact of RTIL ion adsorption on r...

INTRODUCTION The aim of this work was to examine the influence of quercetin on chronic intoxication of rats with ammonium fluoride. A 1:1 mixture of quercetin 8,5' disulfonic acid sodium salts (Na2QDSA): NaQSA-5' and NaQSA-8 (Figure 1), synthesized at the Department of Inorganic Chemistry, Technical University of Rzeszów, was used. Pharmacological investigations have demonstrated the diverse ac...

The ion-transport properties of the basal lateral membranes of intact isolated parietal cells were studied at the cellular and subcellular level. The presence of an amiloride-sensitive Na+:H+ exchange was demonstrated in cells by proton gradient-driven Na+ uptake and by changes in cell pH as monitored by dimethylcarboxylfluorescein fluorescence both in a fluorimeter and on single isolated cells...

The addition of 1,4-diazabicyclo-[2,2,2]octane (DABCO) (100 mM) or 1,2-dihydroxybenzene-3,5-disulfonic acid (Tiron) (1 mM) to a reaction mixture containing 10 mM linoleic acid (LA), 20% EtOH, and 135 microM dehydroascorbic acid (DHA) as a catalyst suppressed LA peroxidation, but the addition of mannitol (approximately 100 mM), uric acid (100 microM), and catalase (6.5 units) did not. DHA or 2,3...

friedel–crafts synthesis of triarylmethanes over 3-methyl-1-sulfonicacid imidazolium tetrachloroaluminate under green conditions:in this work, friedel–crafts (fc) alkylation of various arenes with aromatic aldehydes catalyzed by 3-methyl-1-sulfonic acid imidazoliumtetrachloroaluminate {[msim]alcl4}, as a green catalyst, to prepare triarylmethanes (tams) has been carried out. some aromatic aldeh...

Several novel methods for reliably carrying out the oligonucleotide synthesis via the phosphoramidite strategy have been developed. The first is the method using allyloxycarbonyl and allyl groups for the protection of nucleoside bases and internucleotide linkages, respectively. These protectors can be cleanly removed under almost neutral conditions with a mixture of an organic Pd(0) complex suc...