Cox17, a copper chaperone for cytochrome-c oxidase, is an essential and highly conserved protein in eukaryotic organisms. Yeast and mammalian Cox17 share six conserved cysteine residues, which are involved in complex redox reactions as well as in metal binding and transfer. Mammalian Cox17 exists in three oxidative states, each characterized by distinct metal-binding properties: fully reduced m...

The 2S electron bubble placed in liquid helium has been previously believed to be spherical. We show that the 2S bubble is morphologically unstable at pressures above -1.23 bars. The 2S state being known to be radially unstable at pressures below -1.33 bars, the result leaves only a very narrow pressure range in which it can be found in a spherical configuration. Our stability analysis indicate...

Glutaredoxins (Grxs) constitute a superfamily of proteins that perform diverse biological functions. The Saccharomyces cerevisiae glutaredoxin Grx6 not only serves as a glutathione (GSH)-dependent oxidoreductase and as a GSH transferase, but also as an essential [2Fe-2S]-binding protein. Here, the dimeric structure of the C-terminal domain of Grx6 (holo Grx6C), bridged by one [2Fe-2S] cluster c...

Among the proteinogenic amino acids, only proline is a secondary amine and only proline has a saturated ring. Electronegative substituents on C-4 (that is, C(gamma)) have a substantial effect on the trans/cis ratio of the prolyl peptide bond and the pucker of the pyrrolidine ring. 2-Azabicyclo[2.1.1]hexane is, in essence, a proline analogue with two C(gamma) atoms, one in each of the two preval...

Full (1)H and (13)C NMR chemical shift assignments were made for two sets of penam beta-lactams: namely, the diastereomeric (2S, 5S, 6S)-, (2S, 5R, 6R)-, (2S, 5S, 6R)-, and (2S, 5R, 6S)-methyl 6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylates (1-4) and (2S, 5R, 6R)-, (2S, 5S, 6R)-, and (2S, 5R, 6S)-6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4...

Teneraic acid (piperidine-2,6-dicarboxylic acid) is a naturally occurring imino acid that comprises three stereoisomers due to its two asymmetric centers at C2 and C6. The configuration of natural teneraic acid is reported to correspond to trans-(2S,6S). However, a few studies are focused on the stereospecific synthesis of trans-(2S,6S)-teneraic acid. The present study investigates a convenient...

Working in the nonrelativistic-QCD factorization framework at next-to-leading order ${\ensuremath{\alpha}}_{s}$, we fit relevant color octet long-distance matrix elements of $\ensuremath{\psi}(2S)$ meson, $⟨{\mathcal{O}}^{\ensuremath{\psi}(2S)}({^{1}S}_{0}^{[8]})⟩$, $⟨{\mathcal{O}}^{\ensuremath{\psi}(2S)}({^{3}S}_{1}^{[8]})⟩$, and $⟨{\mathcal{O}}^{\ensuremath{\psi}(2S)}({^{3}P}_{0}^{[8]})⟩$, to...

We analyze the 1496 days of SuperKamiokande data to put limits on the νe, ν̄e, νμ + ντ and ν̄μ + ν̄τ components of the diffuse flux of supernova neutrinos, in different energy intervals and for different neutrino energy spectra. By considering the presence of only one component at a time, we find the following bounds at 90% C.L. and for neutrino energy E > 19.3 MeV: Φνe < 73.3 − 154 cm−2s−1, Φν̄e <...

We study interior Lp-regularity theory, also known as Calderon-Zygmund of the equation〈Lsu,φ〉:=∫Rn∫RnK(x,y)(u(x)−u(y))(φ(x)−φ(y))|x−y|n+2sdxdy=〈f,φ〉,∀φ∈Cc∞(Rn). prove that for s∈(0,1), t∈[s,2s], p∈[2,∞), K an elliptic, symmetric, and K(⋅,y) is uniformly Hölder continuous, solution u belongs to Hloc2s−t,p(Ω) long 2s−t<1 f∈(H00t,p′(Ω))⁎. The increase in differentiability integrability independent...