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General anesthesia is associated with inherent risks that can be avoided less invasive anesthetic strategies. We hypothesized the use of local or regional (LRA) would as safe and effective general (GA) for patients undergoing thoracic endovascular aortic repair (TEVAR). Patients who had undergone TEVAR from 2010 to 2020 in Vascular Quality Initiative were analyzed. The exclusion criteria includ...
See related article, pages 2433–2437. Numbers needed to treat (NNT) is a powerful tool that has been proposed to translate research findings of treatment effects to an intuitive figure for clinical settings or for policy-making purposes. It is a measure of clinical benefits that describes the number of individuals who would need to be treated to prevent the occurrence of 1 outcome event.1 NNT, ...
Background: We performed an updated meta-analysis of randomized placebo-controlled trials testing memantine monotherapy for patients with Alzheimer’s disease (AD). Methods: The meta-analysis included randomized controlled trials of memantine monotherapy for AD, omitting those in which patients were also administered a cholinesterase inhibitor. Cognitive function, activities of daily living, beh...
Background: We performed an updated meta-analysis of randomized placebo-controlled trials testing memantine monotherapy for patients with Alzheimer’s disease (AD). Methods: The meta-analysis included randomized controlled trials of memantine monotherapy for AD, omitting those in which patients were also administered a cholinesterase inhibitor. Cognitive function, activities of daily living, beh...
The growth in the use of interconnected devices in the UK is well-documented. Society has embraced new technology allowing access to information, systems, and people; children are being described as digital natives and social networking, internet telephony, and accessing digital entertainment are a major part of their lives. However, whilst the ubiquitous nature of modern communication systems ...
The Human Genome Project has increased the rate of DNA sequence accumulation to the point where information management has become a formidable task. The central repositories for this avalanche of data, GenBank, EMBL (European Molecular Biology Laboratory), and DDBJ (DNA Data Bank of Japan), continue to accumulate DNA sequences at an unprecedented rate. For example, the total number of nucleotid...
L-Selenocysteine (Sec or U) has been called the “21st amino acid”.1 Like the twenty common amino acids, selenocysteine is inserted during the translation of mRNA and has its own tRNASec and codon, UGA. This codon also serves as the opal stop codon. Decoding a UGA codon as one for selenocysteine requires a special structure in the 3′ untranslated region of the mRNA called a selenocysteine insert...
Fibroblast growth factor 1 (FGF-1) enhances apolipoprotein E (apoE) expression and apoE-HDL biogenesis in autocrine fashion in astrocytes (Ito, J., Y. Nagayasu, R. Lu, A. Kheirollah, M. Hayashi, and S. Yokoyama. Astrocytes produce and secrete FGF-1, which promotes the production of apoE-HDL in a manner of autocrine action. J. Lipid Res. 2005. 46: 679–686) associated with healing of brain injury...
The Millikan Library Building, a nine-story reinforced concrete shear-wall structure at the California Institute of Technology, was tested dynamically by means of two eccentric mass vibration generators located on the ninth floor. The response levels ranged up to a maximum acceleration of 0:02 g. The natural periods of vibration, the mode shapes and the energy dissipation were measured for the ...
Escherichia coli RseP, a member of the site-2 protease family intramembrane proteases, is involved in activation σE extracytoplasmic stress response and elimination signal peptides from cytoplasmic membrane. However, whether RseP has additional cellular functions unclear. In this study, we used mass spectrometry–based quantitative proteomic analysis to search for new substrates that might revea...
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