of oral presentations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 232 Abstracts of poster presentations. . . . . . . . . . . . . . . . . . . . . . . . . . . . 237 Abstracts / Molecular Genetics and Metabolism 93 (2008) 221–268 225s of poster presentations. . . . . . . . . . . . . . . . . . . . . . . . . . . . 237 Abstracts / Molecular Genetics and Metabolism 93 (2008) 221–268 225

OBJECTIVES Neuropsychiatric symptoms and anosognosia are known to influence the perceived quality of life of patients (QoL-p) with Alzheimer's disease (AD). This study analysed their impact on patient and caregiver ratings of QoL-p and how these ratings changed in relation to the severity of dementia. METHODS A baseline sample of 221 patients and caregivers was followed up over 24 months. Ins...

Base rates of impairment on the Temporal Orientation Scale (TOS; Benton et al.,) were reported for normal elderly (n=210) and patients with either Alzheimer’s disease (AD; n=112) or Parkinson’s disease (PD; n=189). The study hypothesis was that disorientation would be more frequent in ADs than in controls and PDs. Base rates for controls, PDs, and ADs were 1.00%, 22.22%, and 78.60% when disorie...

BACKGROUND MicroRNAs (miRNAs) are a class of small non-coding RNAs that have recently emerged as important regulators of gene expression. They negatively regulate gene expression post-transcriptionally by translational repression and target mRNA degradation. miRNAs have been shown to play crucial roles in muscle development and in regulation of muscle cell proliferation and differentiation. M...

Aberrant cholangiocyte reactions in response to inflammatory stimuli are important pathogenic factors for the persistent biliary inflammation in patients with cholangiopathies. Overexpression of intercellular cell adhesion molecule-1 (ICAM-1) in cholangiocytes is a common pathological feature in inflammatory cholangiopathies and can promote cholangiocyte interactions with effector lymphocytes i...

The tyrosine kinase JAK2 is a key signaling protein for at least 20 receptors in the cytokine/hematopoietin receptor superfamily and is a component of signaling by insulin receptor and several G-protein-coupled receptors. However, there is only limited knowledge of the physical structure of JAK2 or which of the 49 tyrosines in JAK2 are autophosphorylated. In this study, mass spectrometry and tw...

BACKGROUND Early detection is a key to survival for gastric cancer. Molecular markers such as miRNA (microRNA) can have great importance in the early diagnosis of gastric cancer. Expression of miR-21 and miR-221 are deregulated in many types of human cancers. This study aimed to investigate the differences in miRNA expression patterns within the Iranian population. METHODS Total RNA was extra...

Adiponectin receptor 1 (AdipoR1) mediates adiponectin's pleiotropic effects in muscle and liver and plays an important role in the regulation of insulin resistance and diabetes. Here, we demonstrate a pivotal role for microRNA-221 (miR-221) and the RNA-binding protein polypyrimidine tract-binding protein (PTB) in posttranscriptional regulation of AdipoR1 during muscle differentiation and in obe...