Abstract Introduction Traumatic spinal cord injury (TSCI) is a subset of neurotrauma, which significant contributor to global trauma mortality and morbidity in children. The management outcomes paediatric TSCI low- middle-income countries (LMICs) unknown. We conducted scoping review characterise the methods LMICs. Method MEDLINE, EMBASE, Global Index Medicus were searched from database inceptio...

Alzheimer's disease (AD) is a multifactorial and fatal neurodegenerative disorder for which the mechanisms leading to profound neuronal loss are incompletely recognized. MicroRNAs (miRNAs) are recently discovered small regulatory RNA molecules that repress gene expression and are increasingly acknowledged as prime regulators involved in human brain pathologies. Here we identified two homologous...

BCR-ABL-independent resistance against tyrosine kinase inhibitor is an emerging problem in therapy of chronic myeloid leukemia. Such drug resistance can be linked to dysregulation of ATP-binding cassette (ABC)-transporters leading to increased tyrosine kinase inhibitor efflux, potentially caused by changes in microRNA expression or DNA-methylation. In an in vitro-imatinib-resistance model using...

Since their discovery, miRNAs have emerged as a promising therapeutical approach in the treatment of several diseases, as demonstrated by miR-212 and its relation to addiction. Here we prove that the miR-212/132 cluster can be regulated by morphine, through the activation of mu opioid receptor (Oprm1). The molecular pathways triggered after morphine administration also induce changes in the lev...

Multilingual generation is becoming an increasingly important aspect of implemented systems that showcase the abilities of generation systems. Most such systems require multiple grammars, one for each language which must be deployed. Yet little is known about the development costs for additional languages which are developed not from scratch, but by adapting existing resources. We ported a stan...

aim : this study evaluated the results and efficacy of serum ca 19-9 in determining the nature of a pancreatic solid mass in patients referred for investigation of possible malignancy. background : a wide variety of tumor markers have been proposed for pancreatic cancer but currently the only one with any practical usefulness for diagnosis, prognosis, and monitoring of treatment is “ca 19-9 ”. ...

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