Alzheimer's disease (AD) is an age-related irreversible neurodegenerative disorder characterized by extracellular β Amyloid(Aβ) deposition, intracellular neurofibrillary tangles and neuronal loss. The dysfunction of neurogenesis and increased degeneration of neurons contribute to the pathogenesis of AD. We now report that miR-211-5p, a small non-coding RNA, can impair neurite differentiation by...

The present study evaluated the single and mixed toxicities of commonly used antifouling biocides (copper pyrithione, Sea nine 211, dichlofluanid, tolylfluanid, and Irgarol 1051) on the early embryogenesis of sea urchin Strongylocentrotus intermedius. Their toxicities were quantified in terms of the median effective concentration (EC50) reducing the embryogenesis success by 50%. For individual ...

Neuropathic pain is a debilitating pathological condition of high clinical relevance. Changes in neuronal excitability in the anterior cingulate cortex (ACC) play a central role in the negative emotional and affective aspects of chronic pain. We evaluated the effects of LP-211, a new serotonin-receptor-type-7 (5-HT7R) agonist that crosses the blood-brain barrier, on ACC neurons in a mouse model...

The main standards now being implemented in the geospatial world emanate from the International Organization for Standardization (ISO) Technical Committee 211 Geomatics/Geographic Information (generally referred to as ‘TC 211’), in their 19xxx series of standards. Because some EU Member States have legal requirements that ‘European standards’ be used for various types of work, if they exist, th...

PKS1830-211 is an unusually radio−loud gravitationally lensed quasar. In the radio, the system appears as two compact, dominant features surrounded by relatively extended radio emission which forms an Einstein Ring. As the line of sight to it passes close to our Galactic center, PKS1830-211 has not been detected in wave-bands other than the radio and X-ray so far. Here we present X-ray data of ...

BACKGROUND AND OBJECTIVES To cater to the needs of informed and proactive patients in family medicine, health care providers could offer access to care and health information via practice Web sites. To determine the content and quality of family medicine Web sites, we performed a cross-sectional study on a large sample of family practices' Web sites in Berlin, Germany. METHODS After screening...

The cross-talk at the prefronto-striatal interface involves excitatory amino acids, different receptors, transducers and modulators. We investigated long-term effects of a prepuberal, subchronic 5-HT7-R agonist (LP-211) on adult behaviour, amino acids and synaptic markers in a model for Attention-Deficit/Hyperactivity Disorder (ADHD). Naples High Excitability rats (NHE) and their Random Bred co...

To identify genes associated with morphological phenotypes of human bladder transitional cell carcinoma, we used suppression subtractive hybridization (SSH) to create a subtractive cDNA library of two established cell lines, BLZ-211 and BLS-211, derived from a patient with transitional cell carcinoma of the bladder, then to screen for differentially expressed genes. Real-time reverse transcript...

Endocrinologists are encountering patients with obesity-related complications such as metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) on a daily basis. Nonalcoholic fatty liver disease (NAFLD) is a liver condition characterized by insulin resistance, hepatic steatosis and frequently T2DM. This is now the most common chronic liver condition in adults and is present in the majority ...

Background: Most carcinomas are prone to metastasize despite successful treatment of the primary tumor. One way to address this clinical challenge may be targeted therapy with α-emitting radionuclides such as astatine-211 (At). Radioimmunotherapy utilizing α-particle emitting radionuclides is considered especially suitable for the treatment of small cell clusters and single cells, although lesi...