MicroRNA-210 (miR-210), the master hypoxamir, plays pleiotropic roles in certain cancers; however, its role in the development of human colorectal cancer remains unclear. Herein, we report that miR-210 is frequently up-regulated in colorectal cancer tissues, with high miR-210 expression significantly correlating with large tumor size, lymph node metastasis, advanced clinical stage and poor prog...

Objective. The aim of this study was to investigate the prognostic value of MicroRNA-210 (miR-210) expression in patients with non-small-cell lung cancer (NSCLC). Methods. We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University from 2004 to 2007, by using quantitative RT-PCR. The relationship between miR-210 expression and c...

This paper reprises examples of C2 and simulation systems that have been implemented using C2Sim standards (C-BML and MSDL). The work covered relates specifically to the UK systems discussed in other papers in this set of lectures but in many cases will apply equally well to other countries’ national systems. It also looks at some of the implementational aspects and gives a number of observatio...