نتایج جستجو برای: 2 deoxy d glucose
تعداد نتایج: 3009542 فیلتر نتایج به سال:
In natural product chemistry, it is often crucial to determine sugar composition as well as the absolute configuration of each monosaccharide in glycosides. An ultra-performance liquid chromatography method using both photodiode array (PDA) and mass spectrometry detectors (UPLC-UV/MS) was developed for qualitative analysis of the absolute configuration of monosaccharide enantiomers. Within a si...
Background: Both mitochondrial dysfunction and aerobic glycolysis are signs of growing aggressive cancer. If altered metabolism of cancer cell is intended, using the glycolysis inhibitor (2-deoxyglucose (2DG)) would be a viable therapeutic method. The AMP-activated protein kinase (AMPK), as a metabolic sensor, could be activated with metformin and it can also launch a p53-dependent metabolic ch...
Fjelde et a!. (9) observed that D-glucosamine inhibited the growth of human epidermoid carcinoma cells in tissue culture, with concentration of 1 mg/mI causing death of the cells within 24 hr. The i.p. administration of divided doses of D-glucosamine or 2-deoxy-D-glucose inhibited the growth of Walker 256 carcinosarcoma in rats without significant toxicity to the host (1). Tumor growth resumed ...
The title compound is a co-crystal of the cis and trans isomers, namely cis-bis-[1,1,1,5,5,5-hexa-fluoro-pentane-2,4-dionato(1-)-κ(2)O,O']bis-(4-phenyl-pyridine N-oxide-κO)copper(II)-trans-bis-[1,1,1,5,5,5-hexa-fluoro-pentane-2,4-dionato(1-)-κ(2)O,O']bis(4-phenyl-pyridine N-oxide-κO)copper(II) (2/1), [Cu(C(5)HF(6)O(2))(2)(C(11)H(9)NO)(2)]. In both isomers, the coordination geometry of the Cu(2+...
BACKGROUND AND PURPOSE Ischemic stroke has been shown to cause hypermetabolism of glucose in the ischemic penumbra. Experimental and clinical data indicate that infarct-related systemic hyperglycemia is a potential therapeutic target in acute stroke. However, clinical studies aiming for glucose control in acute stroke have neither improved functional outcome nor reduced mortality. Thus, further...
The reason(s) for glucose sensitivity in certain cyanobacterial strains is poorly understood. Inactivation of genes encoding the putative sensor kinase Hik31 in Synechocystis sp. strain PCC 6803 resulted in a mutant unable to grow in the presence of D-glucose. Sensitivities to D-glucose, its analogue 2-deoxy-D-glucose, and fructose, were alleviated in mutants in which glcP, encoding the glucose...
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