a new facile route for synthesis of 3- (aryl) -8, 9- di (alkyl) thieno [3,2-e] [1,2,4] triazolo pyrimidines derivative from the same starting material, 2- amino - 4,5 -di (alkyl) thiophene-3- carboxamide, has been developed through heterocyclization of the corresponding arylidene-hydrazino -5,6 -di (alkyl) thieno [2,3-d] pyrimidine under refluxing condition with acetic anhydride followed by air...

Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.

E7070 is a synthetic chloro-indolyl sulphonamide that is being developed as an anti cancer agent. In this phase II study, 28 patients with metastatic melanoma received 700 mg/m(2) of E7070 as a 60-min infusion repeated every 3 weeks. Although therapy was well tolerated, with one patient receiving 14 courses of treatment, there were only minor responses on independent radiological review. E7070 ...

In the title compound, [Ni(C(45)H(34)BN(6))(C(10)H(9)N(3))]Br·CH(2)Cl(2), the Ni(II) atom is five-coordinated by the tridentate hydro-tris-(3,5-diphenyl-pyrazol-yl)borate ligand and a bidentate di-2-pyridyl-amine ligand in a distorted square-pyramidal geometry. In the crystal, inter-molecular N-H⋯Br and C-H⋯Br hydrogen bonds link the Ni complex cations and the Br(-) ions, forming a chain along ...

DL-fi-acetylthioisobutyrate (DL-ester).'} A newly isolated strain, Pseudomonas puticin MR-2068, had been selected as the best DAT producer because of its cnzymatic characterization.2} The enzyme produced by the strain has enhanced thermostability as compared to previously available enzymes. There are many advantages in using thermostable enzymes in industrial processes as compared to thermolabi...

3-(2-Furanyl)-2-propenoic acid has been used to prepare a new series of organotin complexes of general formula R3SnL (R=Me, Et, n-Bu, Ph and Cy) and R2SnL2 (R=Me and n-Bu). These complexes have been characterized by elemental analyses, IR, 1H-NMR, MASS and Mössbaure spectroscopy.

The Rh(II)- and Cu(II)-catalyzed reactions of N-bis(trimethylsilyl)methyl, N-(2-indolyl)methyl α-diazoamides are investigated to delineate how conformational, steric and electronic factors influence the site- and chemoselectivity of the metallocarbenoid reaction. The N-bis(trimethylsilyl)methyl (N-BTMSM) group is found to be essential in promoting the metallocarbenoid reaction at the N-(2-indol...

A FeCl3-catalyzed highly regioselective 1,2-addition/substitution sequence of 3-acetylcoumarins and indoles has been developed to afford highly hindered tetrasubstituted bis(indolyl)methanes bearing a biologically useful coumarin motif in 56-99% yields.

In the lipophilic extracts from Streptomyces cinnamomeus 2-ethyl-5-(3-indolyl)oxazole (1a) was detected by chemical screening methods. The structure of the crystalline 1a was determined by spectroscopic and X-ray analysis. The new mono- and dibromo derivatives 1b and 1c are described. 1a is identical with pimprinethine and belongs to a group of microbial indole alkaloids, which can be regarded ...