in this paper, new (2e, 2'e)-3, 3'-(((3- hydroxypropane-1, 2-diyl) bis (oxy)) bis (2, 1-phenylene)) bis (1-phenylprop-2-en-1-one) (2a) was prepared in good yield by condensation reaction of acetophenone with bisaldehyde (1a) in ethanolic naoh solutions at room temperature. the (2e, 2'e)-3, 3'-(((3- hydroxypropane-1, 2-diyl) bis (oxy)) bis (2, 1-phenylene)) bis (1-phenylprop-...

the present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1h) - ones/thiones. the study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. to find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2-(1h)-one derivatives using aromatic aldehyde,...

Two novel urea anion receptors (11) and (12) were synthesized from building block 3,3’ methylene diamine and was characterized via the techniques of 1H NMR, 13 C NMR, DEPT135 1H-1H COSY, HMQC and HMBC spectroscopy. The 1H NMR profile of both compounds reveals diagnostic peaks. For compound (11), the urea NH protons resonate as two singlets downfield at 8.706 ppm and 8.635 ppm, whereas for compo...

Footrot is a debilitating and contagious disease in dairy cows, caused by the Gram-negative anaerobe Dichelobacter nodosus. 1H-NMR (nuclear magnetic resonance)-based metabolomics has been previously used to understand the pathology and etiology of several diseases. The objective of this study was to characterize serum from dairy cows with footrot (n=10) using 1H-NMR-based metabolomics and chemo...

BACKGROUND The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics. METHODS Metabolomic profiling, employing 1H-NMR, 1H-NMR T2-edited, and 2D-NMR spectroscopy and chemometrics of human blood serum samples from patients with bipolar disorder (n = 26) compared wit...

The purpose of the present study was to establish an experimental method to study the effects of quercetin on the metabolism of the drug-resistant leukemia cell line K562/ADM using nuclear magnetic resonance (NMR) technology. Drug administration to the cells was performed according to proper experimental design and application. The cells were collected and inactivated by repeated freeze-thaw cy...

from hexanic extract of aerial parts of peucedanum ruthenicum m. bieb (apiaceae) collected from mazandaran province of iran, four triterpenoids namely taraxasterol, y-taraxasterol, poriferasterol and b-sitosterol have been isolated by column chromatography, thin layer chromatography, and crystallization. their structures were elucidated by spectroscopic methods (uv, ir, ms, 1h and 13c-nmr).

Puerariae Flos, the flowers of Pueraria. lobata (WILLD.) OHWI, is an important oriental crude drug used to ameliorate crapulence. In the preceding paper,' we described two triterpenoidal glycosides of the sophoradiol glucuronides, along with the known six aromatic compounds, kakkalide, daidzin, genistin, rutin, robinin and nicotiflorin. This paper further deals with a tryptophan derivative, ten...

Recent applications of high-field NMR spectroscopy in biosynthesis will be discussed. The emphasis of the lecture will be on the use of 1H, 3H, '3C and '5N-NMR to focus on individual steps of biochemical processes in the formation of natural products and related enzyme-catalyzed events. In the first set of experiments, pulse labelling and invivo studies are used to uncover biosynthetic sequence...