BACKGROUND The two main mechanisms of resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) are the occurrence of T790M secondary mutation in the kinase domain of EGFR and MET amplification. The aim of the present study was to test whether early changes of 18F-fluorodeoxyglucose (18F-FDG) uptake in animal models bearing erlotinib-resistant NSCLC may have dif...

PURPOSE Inhibition of the protein kinase mammalian target of rapamycin (mTOR) is being evaluated for treatment of a variety of malignancies. However, the effects of mTOR inhibitors are cytostatic and standard size criteria do not reliably identify responding tumors. The aim of this study was to evaluate whether response to mTOR inhibition could be assessed by positron emission tomography (PET) ...

invasive apocrine carcinoma (iac) of the breast is a rare subtype of breast malignancy. its incidence is not well known, but it is approximately less than 1% to 4%. for these reasons, there are few reports and little information on the radiologic appearance of iac. furthermore, most of the case reports show malignant features which are similar to invasive ductal carcinoma (idc). we present a ra...

The statistical analysis of positron emission tomography (PET) standardized uptake value (SUV) measurements is challenging due to the skewed nature of SUV distributions. This limits utilization of powerful parametric statistical models for analyzing SUV measurements. An ad-hoc approach, which is frequently used in practice, is to blindly use a log transformation, which may or may not result in ...

Aim: It was aimed to evaluate the prognostic role of primary tumor metabolic-volumetric parameters 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in resectable tongue squamous cell carcinoma (TSCC).Material and Method: The imaging findings 44 TSCC patients (23 females, 21 males, mean age: 58±12 years) with tumors who underwent 18F-FDG PET/CT for stagi...

ObjectiveThis study aimed to investigate the value of interim whole-body dynamic 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) Patlak parameters for predicting prognosis patients with diffuse large B-cell lymphoma. To estimate predictive 18F-FDG PET/CT parameter 2-year progression-free survival (PFS) and overall (OS).MethodsThis reports findings 67 lym...

Abstract Background Infective endocarditis is a challenging diagnosis that usually requires cardiovascular image confirmation as part of the approach. 18F-FDG PET/CT an imaging technique more sensible for prosthetic valve when echocardiography inconclusive. Case Summary We present case 35-year-old man who had previous Bentall-De Bono procedure four years prior included biological, INC-type, loc...

Positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) has been successfully evaluated in the management of non-Hodgkin's lymphoma (NHL).1-3 Histological transformation (HT) of indolent lymphoma is a dramatic event that occurs in 5-10% of the patients and carries a dismal prognosis.4,5 Previous studies prove that indolent lymphoma entities show a lower FDG uptake when compared with...

Positron Emission Tomography - Computed (PET-CT) has been used to diagnose malignancy before surgery. However, there may be an increase in 18F-fluorodeoxyglucose (FDG) uptake PET scans benign conditions, leading a false-positive diagnosis of and unnecessary This PET-CT investigation is expensive not without risk, including radiation drug or contrast hypersensitivity. Although variable uterine u...