Endothelial cell (EC) Ca-activated K channels (SKCa and IKCa channels) generate hyperpolarization that passes to the adjacent smooth muscle cells causing vasodilation. IKCa channels focused within EC projections toward the smoothmuscle cells are activated by spontaneous Ca events (Ca puffs/pulsars). We now show that transient receptor potential, vanilloid 4 channels (TRPV4 channels) also cluste...

In this paper we present INTEGRAL observations of 7 AGNs: two newly discovered type 1 Seyferts, IGR J18027-1455 and IGR J21247+5058, and five well known Seyferts, NGC 6814 (type 1.5), Cyg A (Type 2), MCG-05-23-16 (type 2), ESO 103-G035 (type2) and GRS1734-292. For IGR J18027-1455 and IGR J21247+5058 only INTEGRAL/IBIS data were available, while broadband spectra are presented and discussed for ...

Earlier reports suggest that the endocannabinoids may play a role of endogenous tumor growth modulators. In this study, we investigated whether inhibition of the enzymes involved in the synthesis and degradation of endocannabinoids may reduce colorectal cancer cell invasion and migration. The human colon adenocarcinoma Colo-205 cells were incubated with PF-3845, JZL-184 and RHC-80267 (fatty aci...

The Library of the Jesuit college in Lviv is known as biggest and best-equipped library city. It was founded at beginning 17th century, after one hundred years, there were approximately 12,000 books. But a huge loss books great fire 1734. After that Jesuits restored their book collection. Historiography says 10,000 time dissolution Society Jesus.
 Unfortunately, it impossible to verify inf...

The author focuses on one of the most important terms normative aesthetics and art, decency, which occupies a prominent place in writings Prince Dmitry Golitsyn (1734–1803), devoted to issues architecture fine arts. A detailed study origins decency meaning this concept leads identification three stages its development, consistently considered with involvement both source texts works modern scho...

OBJECTIVE To assess an internet-delivered intervention providing advice to manage respiratory tract infections (RTIs). DESIGN Open pragmatic parallel group randomised controlled trial. SETTING Primary care in UK. PARTICIPANTS Adults (aged ≥18) registered with general practitioners, recruited by postal invitation. INTERVENTION Patients were randomised with computer-generated random numbe...

The transient receptor potential vallinoid type 4 (TRPV4) is a calcium entry channel known to modulate vascular function by mediating endothelium-dependent vasodilation. The present study investigated if isolated cerebral arterial myocytes of the Fawn Hooded hypertensive (FHH) rat, known to display exaggerated KCa channel current activity and impaired myogenic tone, express TRPV4 channels at th...