BACKGROUND In this study we examined the in vivo and in vitro effects and mechanisms of action of curcumin on the development of acute graft-versus-host disease (GVHD) using a murine model. METHODOLOGY/PRINCIPAL FINDINGS Mixed lymphocyte reactions were used to determine the in vitro effects of curcumin. Treatment with curcumin attenuated alloreactive T cell proliferation and inhibited the pro...

Cholestasis is a serious manifestation of liver diseases with limited therapies. Rhubarb, a widely used herbal medicine, has been frequently used at a relatively large dose for treating cholestasis. However, whether large doses are optimal and the therapeutic mechanism remain unclear. To explore these questions, the anti-cholestatic effect of five doses of rhubarb (0.21, 0.66, 2.10, 6.60, and 2...

Curcumin is the active component of Curcuma species including C. longa (turmeric). This molecule is well known for its anti-inflammatory effect, which seems to be stronger than that of hydrocortisone. Curcuma species have been used in Asian traditional medicine as topical anti-inflammatory drugs. Curcumin has poor oral bioavailability and its topical application could be of choice, particularly...

Incorporation of the coloring agent, tartrazine and curcumin affects healthy physiological system leading to changes in hematology, biochemistry enzymatic activity. Consequences oral administration were explored for 15, 30 45 days female adult rat. Two doses based on admissible daily intake (ADI) 9.6 96 (high) mg/kg/body weight tartrazine, 3.85 38.5 curcumin. Phytochemicals such as saponins, gl...

The aim of the present investigation was to develop and study topical gel delivery of curcumin for its anti-inflammatory effects. Carbopol 934P (CRB) and hydroxypropylcellulose (HPC) were used for the preparation of gels. The penetration enhancing effect of menthol (0-12.5% w/w) on the percutaneous flux of curcumin through the excised rat epidermis from 2% w/w CRB and HPC gel system was investi...

Objective Indiscriminate use of synthetic pyrethroid insecticides, Cypermethrin (Cyp) and Deltamethrin (Del) have been reported to cause system toxicity in mammals including humans. The dietary antioxidants protects tissues and organs against insecticides/xenobiotic induced damage. In present study, we evaluated the effect of exposure of Cyp and Del and possible protective roles of curcumin and...

BACKGROUND There are contradictory results from studies on the effect of curcumin, a plant phenolic compound with a well-established anticancer effect in vitro, on the action of etoposide in cancer cells. OBJECTIVE The aim of this study was to evaluate the influence of curcumin on the genotoxic and cytostatic action of etoposide in the LT12 cell line derived from BN rat acute myeloid leukemia...

The aim of this study was to observe the inhibitory effect of curcumin on endometriosis (EMS) and to determine its influence on vascular endothelial growth factor (VEGF) and microvessel density (MVD) in eutopic and ectopic endometrium of experimental rats, thus exploring the pathogenesis of EMS offering more experimental evidence for the clinical use of curcumin. Forty-eight female virgin rats ...

The present study was carried out to investigate the synergistic apoptotic potential of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma (MM) cell line U266 , in vitro. U266 cells were cultured with MGN-3 (50 or 100μg/ml) and curcumin (2.5-10μM) for 3 days. The effects of MGN-3 and curcumin on the growth and survival of the U266 cells were determined by t...

various diseases including neurodegenerative diseases, myocardial ischemia-reperfusion injury and cancer. Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5,dione], the principal yellow pigment isolated from turmeric (Curcuma longa Linn), is known as a potent antioxidant comparable to a-tocopherol. Its antioxidant activities have been studied in several in vitro models. Despite its...