The activity of the oestradiol-17 beta hydroxysteroid dehydrogenase in human endometrial and breast cancer specimens was determined by the NAD-dependent conversion of oestradiol-17 beta to oestrone. The sensitivity of the determination was improved by the separation of the hormones by HPLC. We are now able to determine oestradiol-17 beta hydroxysteroid dehydrogenase quantitatively in cryostat s...

The FABGL gene encodes a nicotinamide adenine dinucleotide (NAD)-dependent 17β-hydroxysteroid dehydrogenase (17b-HSD) which is responsible mainly for immune response. It can also regulate the concentration of biologically active estrogens and androgens. It is appear as oxidative enzyme that inactivates estradiol, testosterone, and dihydrotestosterone as well as reductive enzyme by synthesis of ...

Polycystic ovary syndrome (PCOS) is the most common gynaecological disorder among reproductive-age women. Impaired metabolism of androgens and estrogens one leading causes PCOS. In India, medicinal herbs are being explored for their anti-androgenic anti-estrogenic properties. this study, we have screened seed extracts herbal plant, Caesalpinia bonducella potent inhibitors estrogen testosterone ...

Hydroxysteroid dehydrogenase belongs to the subfamily of short-chain dehydrogenases/reductases (SDR), and 11-beta-hydroxysteroid dehydrogenase catalyzes the interconversion of inactive glucocorticoids (cortisone in human, dehydrocorticosterone in rodents) and active glucocorticoids (cortisol in human, corticosterone in rodents). We report here the cloning and characterization of a novel human S...