Thrombocytopenia is a critical problem that occurs in many hematologic diseases, as well as after cancer therapy and radiation exposure. Platelet transfusion is the most commonly used therapy but has limitations of alloimmunization, availability, and expense. Thus, the development of safe, small, molecules to enhance platelet production would be advantageous for the treatment of thrombocytopeni...

Acute and chronic lung inflammation is associated with numerous important disease pathologies including asthma, chronic obstructive pulmonary disease and silicosis. Lung fibroblasts are a novel and important target of anti-inflammatory therapy, as they orchestrate, respond to, and amplify inflammatory cascades and are the key cell in the pathogenesis of lung fibrosis. Peroxisome proliferator-ac...

An ongoing debate on decision and cost-utility analyses is whether to use preferences of general public or patients. The aim of this study was to replicate the valuation procedure of the multi-attribute utility generic measure, 15D, using a sample of multiple sclerosis (MS) patients and to assess its psychometric properties. Consecutive outpatient MS patients were recruited from two MS centers ...

i ya:i = 1 ∀ a ∈ {1 . . . n} , (15d) ya:i ≥ 0 ∀ a ∈ {1 . . . n} ∀ i ∈ L . (15e) Here, the shorthand notation ∑ a,b6=a denotes the summation over both variables a and b such that a 6= b, writing it explicitly: ∑ a ∑ b 6=a. Furthermore, the shorthand ∀ a, b 6= a denotes for all a ∈ {1 . . . n} and b ∈ {{1 . . . n}, b 6= a}. Note that, these shorthand notations are consistent with the main paper, ...

Cellular oxidative stress plays an important role in retinal pigment epithelial (RPE) cell death during aging and the development of age-related macular degeneration. Early reports indicate that during phagocytosis of rod outer segments, there is an increase of RPE oxidative stress and an upregulation of PPARgamma mRNA in these cells. These studies suggest that activation of PPARgamma may modul...

Induction of differentiation and apoptosis in cancer cells by ligands of PPARgamma is a novel therapeutic approach to malignant tumors. Chondrosarcoma (malignant cartilage tumor) and OUMS-27 cells (cell line established from grade III human chondrosarcoma) express PPARgamma. PPARgamma ligands inhibited cell proliferation in a dose-dependent manner, and induced apoptosis of OUMS-27. The higher-g...

We propose that the extraordinary “winking star” KH 15D is an eccentric pre–mainsequence binary that is gradually being occulted by an opaque screen. This model accounts for the periodicity, depth, duration, and rate of growth of the modern eclipses; the historical light curve from photographic plates; and the existing radial velocity measurements. It also explains the re-brightening events tha...

We propose that the extraordinary “winking star” KH 15D is an eccentric pre–mainsequence binary that is gradually being occulted by an opaque screen. This model accounts for the periodicity, depth, duration, and rate of growth of the modern eclipses; the historical light curve from photographic plates; and the existing radial velocity measurements. It also explains the re-brightening events tha...

We present results of the photometric observations of the young eclipsing binary KH 15D obtained during the two observational seasons of 2002-2004 years. A comparison of our data with those by Hamilton et al. (2001) and Herbst et al. (2002) reveals an existence of the long-term photometrical brightness trend: during 5 years a system brightness in the I band decreased by about one stellar magnit...

We present the results of a high-resolution spectroscopic monitoring program of the eclipsing pre–main-sequence star KH 15D that reveal it to be a singleline spectroscopic binary. We find that the radial velocity is variable with an observed range of 10.7 km s. The best-fitting Keplerian model has an orbital period P = 48.38 days, which is nearly identical to the photometric period. Thus, we fi...