ith the aging population and recognition that treatment of a patient’s pain is a key healthcare objective, more patients are taking pain medications that must be taken consistently to be effective. But at the same time, many of these same medications are subject to abuse. These benefits and dangers drive the need to test for patient compliance. Although urine has historically been the specimen ...

Rapid advances in mobile computing and wireless communication present an opportunity for fundamental changes in engineering education, particularly for teambased courses in which collaborative learning is the dominant learning mode. This talk describes a collaborative, multi-disciplinary design course and a suite of collaboration tools called Handy Andy, to support team based design. The curren...

Besides its role as an essential regulator of physiologic and pathologic angiogenesis, vascular endothelial growth factor (VEGF) triggers growth, survival, and migration of leukemia and multiple myeloma cells; plays a pivotal role in hematopoiesis; inhibits maturation of dendritic cells; and increases osteoclastic boneresorbing activity as well as osteoclast chemotaxis. Dysregulation of VEGF ex...

/19r cont'd/ Monday Decr. Ist. We are at last come to a new month-which has been ushered in in Paris by very powerful winds from the W. The weather altogether seems to approach nearly to the NoVr. weather of England. Went down to the Hotel Dieu this morning. Breschet [did] not come, followed Chomel. Went thence to the Hop'. St. Louis. Saw a fine collection of cases, particularly some excellent ...

A. The endogenous opioid system and natural reinforcement 1383 B. The endogenous opioid system and drugs of abuse 1387 C. Perspectives: extending studies to animal models of drug addiction 1393 IV. Genetic Manipulation of the Opioid System, Reinforcement, and Drug Dependence 1393 A. Opioid receptor knockout mice 1393 B. Opioid peptide knockout mice 1394 C. Conclusion 1395 D. Perspectives: towar...

Upon the technological advancement of production flexibility, supply chain agility, and customer behavioral tracking, many online businesses now develop their customization strategies. In this regard, this study proposes an integrative framework for customization of product information, transaction handling, product attribute, and sales’ service. We are interested in how these customizations af...