BACKGROUND The indications for pegylated liposomal doxorubicin (doxil) are expanding. We, therefore, wished to assess the safety of delivering doses exceeding 500 mg/m2 of doxil to patients with solid tumors. PATIENTS AND METHODS Subjects accrued to eight phase I and II protocol studies conducted at two institutions, were assessed for cardiac function at baseline and at specified intervals by...

Three experiments were conducted to study the dietary choline requirement of young swine. Ninety pigs (three replicates), in the first experiment, and 120 pigs (four replicates), in the second experiment, were allotted to the five choline treatments (0, 330, 660, 990 or 1320 mg choline/kg of diet), fed in a 23% crude protein, semi-purified diet (.31% methionine, .33% cystine). The combined resu...

BACKGROUND Among older adults, integration of health services in a continuum of care with case management programs was shown to reduce progression of functional decline, hospitalization, and institutionalization. We hypothesized that such an approach may also result in a higher rate of use of preventive strategies and lower caregiver distress. METHODS Data were from the baseline assessment of...

BACKGROUND A web-based tool was developed and piloted by being made available to healthcare staff in Wales from September 2012 to March 2013. This evaluation included two primary outcome measures: general health and mental well-being, and six secondary outcome measures: sickness absence, alcohol use, healthy eating, smoking, physical activity and maintaining a healthy BMI. The aim was to assess...

The molecular basis of the classical human phosphoglucomutase 1 (PGM1) isozyme polymorphism has been established. In 1964, when this genetic polymorphism was first described, two common allelozymes PGM1 and PGM1 2 were identified by starch gel electrophoresis. The PGM1 2 isozyme showed a greater anodal electrophoretic mobility than PGM1 1. Subsequently, it was found that each of these allelozym...

OBJECTIVES Venous disease was proposed as a cause of restless legs syndrome (RLS) by Dr Karl A Ekbom in 1944, but has since remained largely unexplored. This study examines the effect of endovenous laser ablation (ELA) in patients with concurrent RLS and duplex-proven superficial venous insufficiency (SVI). METHODS Thirty-five patients with moderate to very severe RLS (as defined by the 2003 ...

For preventing erosive wear in dentine, coating with adhesives has been suggested as an alternative to fluoridation. However, clinical studies have revealed limited efficacy. As there is first evidence that Sn(2+) increases bond strength of the adhesive Clearfil SE (Kuraray), the aim of the present study was to investigate whether pre-treatment with different Sn(2+)/F(-) solutions improves the ...

This study aims to examine the essence of principle balance in agreement and dissect position as legal reason for cancellation an order realize equitable law Indonesia. The research method used this is doctrinal by using a statutory approach, conceptual comparative approach. Based on conducted, it was found that emphasizes existence or equality rights obligations parties agreement. Furthermore,...