we report a case of florid polypoid endometriosis presenting with advanced bulky disease in pelvis with serum ca – 125 levels of 7844u/ml. the extent of tumor, ct scan findings, elevated serum ca – 125 levels were suggestive of ovarian malignancy. histopathology demonstrated endometrial glands and stroma. glands were neither crowded nor complex and were separated by a fibromatous stroma that co...

We have used a ribonuclease protection assay to investigate RNase H cleavage of HIV-1 mRNA mediated by phosphorothioate antisense oligonucleotides complementary to the gag region of the HIV-1 genome in vitro. Cell lysate experiments in H9 and U937 cells chronically infected with HIV-1 IIIB showed RNase H cleavage of unspliced gag message but no cleavage of spliced message which did not contain ...

Here, we determined the sequence of a cDNA encoding a guanylic acid-specific ribonuclease (RNase He1) from Hericium erinaceus that exhibits high sequence identity (59%) with RNase Po1, an enzyme with anti-cancer activity and which is found in Pleurotus ostreatus. RNase He1 and RNase Po1 have similar structures and heat stabilities; hence, RNase He1 may also have potential as an anti-cancer agen...

The in vitro and in vivo analysis of the ribonuclease E-deficient (rne-) and the altered mRNA stability protein-deficient (ams-) strains of Escherichia coli has demonstrated that they carry mutations in the same structural gene. Strains encoding either thermolabile RNase E (rne-3071) or Ams protein (ams-1) are defective in both rRNA processing and mRNA turnover. Immediately after a shift to the...

Background While cardiac involvement including heart failure represents the first cause of mortality in idiopathic inflammatory myopathies (IM), subclinical alterations may be largely underdiagnosed by conventional tests. CMR T1 mapping may provide more sensitive diagnostic markers of cardiac involvement in both acute and chronic phases in IM irrespective of cardiac function or late gadolinium ...

Niagara Mohawk's PowerChoice proposal has a central goal of creating competitive markets for electric power in the near term. PowerChoice would create an Independent System Operator (ISO) to manage load and, in addition, a competitive wholesale generation market in the form of a Power Exchange. The Power Exchange would operate in a manner similar to financial markets found around the world. By ...

Ribonuclease S (RNase-S) is a complex that consists of two proteolytic fragments of bovine pancreatic ribonuclease A (RNase-A): the S-peptide (residues 1-20) and S-protein (residues 21-124). We have refined the crystal structures of three RNase-S complexes. The first two contain the full-length 20-residue S-peptide and were studied at pHs of 4.75 and 5.5. The third one consists of a truncated f...

[1] In mountainous landscapes the role of periglacial processes in producing sediment is poorly defined, despite evidence of abundant talus slopes. Ice growth in rock has long been recognized as an efficient erosion mechanism, but the effects have not been readily applied to landscape evolution in response to tectonic and climatic forcing. Here, we quantify how and where ice-driven mechanical e...