A stand-alone ultrasound shear wave imaging technology has been developed to quantify and visualize Young's modulus distribution by remotely applying ultrasound radiation force and tracking the resulting microvibrations in soft tissues with ultrafast ultrasound imaging. We report the first preliminary data that detected the distribution of local muscle stiffness within and between resting and c...

The development of a contrast agent for a laser optoacoustic imaging system (LOIS) can significantly widen preclinical and clinical applications of this imaging modality for early detection of cancerous tumors. Gold nanorods were engineered to enhance the contrast for optoacoustic imaging. Under in vivo conditions, 25 microL of gold nanorods solution at a concentration of 1.25 pM were injected ...

Mass spectrometry imaging is employed for mapping proteins, lipids and metabolites in biological tissues in a morphological context. Although initially developed as a tool for biomarker discovery by imaging the distribution of protein/peptide in tissue sections, the high sensitivity and molecular specificity of this technique have enabled its application to biomolecules, other than proteins, ev...

glioblastoma is considered as the most aggressive type of gliomas. its invasive character involves adjacent tissues and hinders the treatment procedure. although surgical resection followed by radiotherapy and chemotherapy have been the standard therapeutic protocol, the incompetency of detection methods to delineate the exact tumor margins results in recurrence of the tumor. nkcc1 (sodium-pota...

Photoacoustic imaging allows absorption-based high-resolution spectroscopic in vivo imaging at a depth beyond that of optical microscopy. Until recently, photoacoustic imaging has largely been restricted to visualizing the vasculature through endogenous haemoglobin contrast, with most non-vascularized tissues remaining invisible unless exogenous contrast agents are administered. Genetically enc...

Optical coherence tomography (OCT) is a widely used structural imaging method. However, it has limited use in molecular imaging due to the lack of an effective contrast mechanism. Gold nanoparticles have been widely used as molecular probes for optical microcopy based on Surface Plasmon Resonance (SPR). Unfortunately, the SPR enhanced backscattering from nanoparticles is still relatively weak c...

The objective of this work is to develop endoscopic subsurface optical imaging technology that will be able to image different tissue components located underneath the surface of the tissue at an imaging depth of up to 1 centimeter. This effort is based on the utilization of existing technology and components developed for medical endoscopes with the incorporation of the appropriate modificatio...

Introduction Paramagnetic chemical exchange saturation transfer (PARACEST) agents use water molecule exchange with lanthanide ions (Ln) and radiofrequency (RF) spin saturation to create negative contrast in MRI [1]. If the rate of exchange between the bound and bulk water locations is much slower than their frequency difference (i.e. kex << Δω) then RF spin saturation at the shifted bound water...

introduction: with the rapid increase in use of lasers in medical treatments, it is important to understand the mechanisms of heat transfer in biological tissues in order to minimize damage to the tissues resulting from extra heat applied. the aim of this study is to investigate the temperature distribution in living biological tissues when laser irradiation is used in a treatment. methods:  in...