BACKGROUND To investigate the potential mechanisms underlying the protective effects of 18α Glycyrrhizin (GL) on rat hepatic stellate cells (HSCs) and hepatocytes in vivo and in vitro. MATERIAL/METHODS Sprague-Dawley (SD) rats were randomly divided into 5 groups: normal control group, liver fibrosis group, high-dose 18α GL group (25 mg/ kg/d), intermediate-dose 18α GL group (12.5 mg/kg/d) and...

Gugulipid (GL), extract of Indian Ayurvedic medicinal plant Commiphora mukul, has been used to treat a variety of ailments. We report an anticancer effect and mechanism of GL against human prostate cancer cells. Treatment with GL significantly inhibited the viability of human prostate cancer cell line LNCaP (androgen-dependent) and its androgen-independent variant (C81) with an IC(50) of ∼1 μM ...

For an algebraically closed base field of positive characteristic, an algorithm to construct some non-zero GL(n − 1)-high weight vectors of irreducible rational GL(n)-modules is suggested. It is based on the criterion proved in this paper for the existence of a set A such that Si,j(A)fμ,λ is a non-zero GL(n − 1)-high weight vector, where Si,j(A) is Kleshchev’s lowering operator and fμ,λ is a no...

Duke and Kowalski in [6] derive a large sieve inequality for automorphic forms on GL(n) via the Rankin-Selberg method. We give here a partial complement to this result: using some explicit geometry of fundamental regions, we prove a large sieve inequality yielding sharp results in a region distinct to that in [6]. As an application, we give a generalization to GL(n) of Duke’s multiplicity theor...

INTRODUCTION The livertaxis of glycyrrhizic acid-conjugated bovine serum albumin (GL-BSA) has been reported in the literature. Now, in this paper, we describe a novel type of drug-targeted delivery system containing 10-hydroxycamptothecin (HCPT) with liver tumor targeting. METHODS First, GL was coupled to BSA then HCPT was encapsulated in GL-BSA by high-pressure homogenization emulsification....

UNLABELLED Herpesvirus entry requires the viral glycoprotein triad of gB and gH/gL to carry out fusion between the virion envelope and a cellular membrane in order to release the nucleocapsid into the target cell. Herpes simplex virus (HSV) also requires glycoprotein gD to initiate the fusion cascade by binding a cell receptor such as nectin 1 or herpesvirus entry mediator (HVEM). While the str...

specification of a lock. What is a suitable abstract specification for a locking structure? To answer this question, we adopt the idea of specifying concurrent data structures via abstract predicates [1] and provide a lock interface in the form of two abstract procedures: lock and unlock. Every data structure, implementing the lock protocol, will require to provide the implementation of these p...

There are no published data regarding the overall dietary glycaemic index (GI) and glycaemic load (GL) of Australian children and adolescents. We therefore aim to describe the dietary GI and GL of participants of the 2007 Australian National Children's Nutrition and Physical Activity Survey (2007ANCNPAS), and to identify the main foods contributing to their GL. Children, aged 2-16 years, who pr...