Acute lymphoblastic leukemia (ALL) represents the most common childhood malignancy. Because patients with T-ALL are more likely to experience induction therapy failure and early relapse compared with the B-cell precursor subtype (BCPALL), there is a high medical need to develop novel treatment strategies for these patients. PR-104, a pre-prodrug currently tested in adult early clinical trials f...

Operation of the PSI cyclotrons has always relied heavily on manual control. Tuning of our high intensity beams for minimum losses is an art still depending on personal skill. An ergonomically good design of the knobbox is therefore essential for good operation. The age of the previous design, and the request to implement the ACS knobbox in the SLS control system based on EPICS, was an opportun...

Miniature unmanned aerial vehicles (UAVs) and unmanned vertical take-off and landing (VTOL) vehicles have become popular due to their compact size, high maneuverability and high payload-to-size ratio. Such vehicles have shown great potential in surveillance and search and rescue; however the “onthe-ground” processing methods implemented are rather insufficient. This paper presents a low cost, h...

Induction of ampC β-lactamase expression can often compromise antibiotic treatment and is triggered by several β-lactams (such as cefoxitin and imipenem) and by the β-lactamase inhibitor clavulanic acid. The novel β-lactamase inhibitor avibactam (NXL104) is a potent inhibitor of both class A and class C enzymes. The potential of avibactam for induction of ampC expression in Enterobacter cloacae...

Kinesin-based transport is important for synaptogenesis, neuroplasticity, and maintaining synaptic function. In an anatomical screen of neurodevelopmental mutants, we identified the exchange of a conserved residue (R561H) in the forkhead-associated domain of the kinesin-3 family member Unc-104/KIF1A as the genetic cause for defects in synaptic terminal- and dendrite morphogenesis. Previous stru...

Improved marrow purging protocols are needed in autologous bone marrow transplantation (BMT) to achieve complete eradication of minimal residual disease. This study investigates the potential of a human major histocompatibility complex (MHC) nonrestricted killer T-cell line (TALL-104) as a new marrow purging agent in a clinical setting. TALL-104 cells can be irradiated without losing cytotoxic ...

A mechanism that confers increased Al resistance in the Arabidopsis thaliana mutant alr-104 was investigated. A modified vibrating microelectrode system was used to measure H+ fluxes generated along the surface of small Arabidopsis roots. In the absence of Al, no differences in root H+ fluxes between wild type and alr-104 were detected. However, Al exposure induced a 2-fold increase in net H+ i...

This paper presents some aspects related to test process of an advanced video system used in remote IP surveillance. The system is based on a Pentium compatible architecture using the industrial standard PC104+. First the overall architecture of the system is presented , involving both hardware or software aspects. The acquisition board which is developed in a special, nonstandard architecture,...

To meet the need of a transmitter of domestic iFTEM type time-domain fixed-wing airborne electromagnetic survey system, we design a control system based on PC104 bus for iFTEM system. This system consists of a driving signal generator, synchronization control system, protection control system, voltage, current monitoring and transmitter waveform monitoring. In the design, we use WinDriver to de...