Hyaluronan (HA) is an extracellular matrix glycosaminoglycan that is present in pancreatic islets, but little is known about its involvement in the development of human type 1 diabetes (T1D). We have evaluated whether pancreatic islets and lymphoid tissues of T1D and nondiabetic organ donors differ in the amount and distribution of HA and HA-binding proteins (hyaladherins), such as inter-α-inhi...

BACKGROUND & AIMS Disruption of the enteric glial cell (EGC) network is an early pathologic feature in Crohn's disease. To determine the contribution of antigen-specific CD8 and CD4 T cells to the breakdown of the EGC network, we studied specific autoimmune targeting of an ectopic antigen expressed by EGCs. METHODS Transgenic mice (GFAP-HA), which express the influenza hemagglutinin (HA) in E...

The endocytotic c-type lectin receptor DEC-205 is highly expressed on immature dendritic cells. In previous studies, it was shown that antigen-targeting to DEC-205 is a useful tool for the induction of antigen-specific Foxp3(+) regulatory T cells and thereby can prevent inflammatory processes. However, whether this approach is sufficient to mediate tolerance in mucosal tissues like the gut is u...

Biological carbon sequestration is considered an important strategy to mitigate climate change. The energy crop Miscanthus × giganteus has great potential. objective of this study was determine: a) the dry matter yield and content in aboveground belowground biomass; b) total balance plant soil pool. conducted continental Croatia (N 45°51′01.32″; E 16°10′35.85″) by destructive harvesting five-ye...

Three high-pressure liquid injection machines were used to inject isazofos into the root zone of tuff;grass plots to evaluate its potential for control of Hoplolaimus galeatus and Tylenchorhynchus dubius. A Rogers root zone injector delivering isazofos at 2.3 kg a.i./ha through 30 degrees and 60 degrees spray tips at 5,000 psi (3.45 x 10 Pascals) significantly reduced nematode populations at 32...

Through estimations of above-and below-ground standing biomass, annual biomass increment, fine root production and turnover, litterfall, canopy respiration and total soil CO 2 efflux, a carbon balance on seasonal and yearly timescales is developed for a Eucalypt open-forest savanna in northern Australia. This carbon balance is compared to estimates of carbon fluxes derived from eddy covariance ...

The article shows for the first time results of studies on aftereffect 4 years a single use dairy industry waste - cake as fertilizer crops in crop rotation link: potatoes spring wheat barley productivity and product quality. In 2017, experimental plot after harvesting remains perennial grasses was mechanically processed with motor cultivator divided into plots 10 m2 following options: 1. Contr...

Shuttle vectors that replicate stably and express selectable phenotypes in both Thermococcus kodakaraensis and Escherichia coli have been constructed. Plasmid pTN1 from Thermococcus nautilis was ligated to the commercial vector pCR2.1-TOPO, and selectable markers were added so that T. kodakaraensis transformants could be selected by DeltatrpE complementation and/or mevinolin resistance. Based o...

To broaden the applicability of adoptive T-cell therapy for the treatment of hematologic malignancies, we aim to start a clinical trial using HA-1-TCR transferred virus-specific T cells. TCRs directed against the minor histocompatibility antigen (MiHA) HA-1 are good candidates for TCR gene transfer to treat hematologic malignancies because of the hematopoiesis-restricted expression and favorabl...

The study was carried out for two consecutive years (2005-06 to 2006-07) to evaluate the wheat response to five different levels (0, 4, 8, 12 and 16 kg ha) of manganese (Mn) alongwith 150-100-60 kg NPK ha application. The experiment was laid out in randomized complete block design (RCBD) with three repeats under irrigated conditions at Agriculture Research Farm Karor, District Layyah. NPK was a...