In C. elegans embryos, a Wnt/MAPK signaling pathway downregulates the TCF/LEF transcription factor POP-1, resulting in a lower nuclear level in signal-responsive cells compared to their sisters. Although the beta-catenin WRM-1 is required for POP-1 downregulation, a direct interaction between these two proteins does not seem to be required, as the beta-catenin-interacting domain of POP-1 is dis...

Transitions between asymmetric (self-renewing) and symmetric (proliferative) cell divisions are robustly regulated in the context of normal development and tissue homeostasis. To genetically assess the regulation of these transitions, we used the postembryonic epithelial stem (seam) cell lineages of Caenorhabditis elegans. In these lineages, the timing of these transitions is regulated by the e...

We introduce the h-deformation of the algebra of functions on the grass-mann supergroup Gr(1|1) via a contraction of Gr q (1|1).

long –term use of some of insecticides on rice striped stem borer (chilo suppressalis walk.) and for the reason the urgency of use of new suspension insecticide an experiment carried out, in paddy fields under condition at rice research institute in rasht, iran.treatments were as follow;1-fipronilg in first generation 2-fipronil g. in second generation 3-fipronil sc in first generation 0.5 lit....

Let F be a field and Gr(i, F ) be the Grassmannian of idimensional linear subspaces of F . A map f : Gr(i, F ) −→ Gr(j, F ) is called nesting if l ⊂ f(l) for every l ∈ Gr(i, F ). Glover, Homer and Stong showed that there are no continuous nesting maps Gr(i, C) −→ Gr(j, C) except for a few obvious ones. We prove a similar result for algebraic nesting maps Gr(i, F ) −→ Gr(j, F ), where F is an al...

In neuronal cells, activated glucocorticoid receptor (GR) translocates to the nucleus guided by the cytoskeleton. However, the detailed mechanisms underlying GR translocation remain unclear. Using gain and loss of function studies, we report here for the first time that the microtubule-associated protein doublecortin-like (DCL) controls GR translocation to the nucleus. DCL overexpression in COS...

Intrauterine growth restriction (IUGR) increases the risk for neurodevelopment delay and neuroendocrine reprogramming in both humans and rats. Neuroendocrine reprogramming involves the glucocorticoid receptor (GR) gene that is epigenetically regulated in the hippocampus. Using a well-characterized rodent model, we have previously shown that IUGR increases GR exon 1.7 mRNA variant and total GR e...

Aberrant TGFbeta signaling is common in human cancers and contributes to tumor metastasis. Here, we demonstrate that Gr-1+CD11b+ myeloid cells are recruited into mammary carcinomas with type II TGF beta receptor gene (Tgfbr2) deletion and directly promote tumor metastasis. Gr-1+CD11b+ cells infiltrate into the invasive front of tumor tissues and facilitate tumor cell invasion and metastasis thr...