Supernormality refers to the tendency to systematically deny the presence of common symptoms (e.g., intrusive thoughts). The current article describes the psychometric qualities of a 37-item self-report measure of supernormality (i.e., Supernormality Scale; SS). The SS was administered to nonclinical individuals (n1⁄4 95), noncriminal psychiatric patients (n1⁄4 28), nonpsychiatric delinquents (...

Tubes are essential for nutrient transport and gas exchange in multicellular eukaryotes, but how connections between different tube types are maintained over time is unknown. In the Drosophila tracheal system, mutations in oak gall (okg) and conjoined (cnj) confer identical defects, including late onset blockage near the terminal cell-stalk cell junction and the ectopic extension of autocellula...

A diet questionnaire (DQ) designed to assess habitual diet and phyto-oestrogen intake was developed. This study aimed to examine the validity of the DQ in men, with and without having prostate cancer. The DQ was validated against alkylresorcinol metabolites measured in urine as objective biomarkers of whole grain wheat and rye (WG) intake, and a 4-d estimated food record (FR) was used for relat...

1 The Rockefeller University Press J. Cell Biol. https://doi.org/10.1083/jcb.201705017 Introduction The plasma membrane (PM) serves as a physical barrier that separates the cytosolic milieu of the cell from the comparatively harsh external chemical environment. It also serves as a sophisticated communication platform through which cells receive and respond to messages from each other, as well a...

The troglomorphic phenotype shared by diverse cave-dwelling animals is regarded as a classical example of convergent evolution. One unresolved question is whether the characteristic eye loss in diverse cave species is based on interference with the same genetic program. Phreatichthys andruzzii, a Somalian cavefish, has evolved under constant conditions in complete darkness and shows severe trog...

In leghorn chickens (Gallus gallus domesticus) of standard breed (large) and bantam (small) varieties, artificial selection has led to females being permanently gravid and sexual selection has led to male-biased size dimorphism. Using respirometry, videography and morphological measurements, sex and variety differences in metabolic cost of locomotion, gait utilisation and maximum sustainable sp...

We have previously described the creation and analysis of a Notch1 activity-trap mouse line, Notch1 intramembrane proteolysis-Cre6MT or N1IP::Cre, that marked cells experiencing relatively high levels of Notch1 activation. Here, we report and characterize a second line with improvedsensitivity (N1IP::Cre) tomark cells experiencing lower levels of Notch1 activation. This improvement was achieved...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 204 No. 7 1209–1218 www.jcb.org/cgi/doi/10.1083/jcb.201312098 JCB 1209 E.J. Hagedorn and L.C. Kelley contributed equally to this paper. Correspondence to David Sherwood: [email protected] E.J. Hagedorn’s present address is Boston Children’s Hospital, Boston, MA 02115. Abbreviations used in this paper: AC, anchor cell; ADF, actin-d...

How the numbers of niches and resident stem cells within a particular organ are determined during development and how they may be modulated or corrected is a question with significant medical implications. In the larval ovary of Drosophila melanogaster, somatic precursors for niches, and germ cells that will become germline stem cells, co-develop. Somatic precursors proliferate during the first...

Methods and Results-—Participants (n=503) were drawn from the Cameron County Hispanic Cohort. Metabolic health was defined as <2 of the following: blood pressure ≥130/85; triglyceride ≥150 mg/dL; high-density lipoprotein cholesterol <40 mg/dL (men) or <50 mg/dL (women); fasting glucose ≥100 mg/dL; homeostasis model assessment of insulin resistance value >5.13; or highsensitivity C-reactive prot...