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تعداد نتایج: 2752679 فیلتر نتایج به سال:
Wnt signaling has a crucial role in synaptic function at the central nervous system. Here we evaluate whether Wnts affect nitric oxide (NO) generation in hippocampal neurons. We found that non-canonical Wnt-5a triggers NO production; however, Wnt-3a a canonical ligand did not exert the same effect. Co-administration of Wnt-5a with the soluble Frizzled related protein-2 (sFRP-2) a Wnt antagonist...
The invasion of activated fibroblasts represents a key pathomechanism in fibrotic diseases, carcinogenesis and metastasis. Invading fibroblasts contribute to fibrotic extracellular matrix (ECM) formation and the initiation, progression, or resistance of cancer. To construct transcriptome-wide signatures of fibroblast invasion, we used a multiplex phenotypic 3D invasion assay using lung fibrobla...
Recent evidence that Wnts and other genes in the Wnt signaling pathway are expressed in embryonic and adult mouse lung suggests that this pathway is important for cell fate decisions and differentiation of lung cell types. We therefore examined the expression and protein distribution of several Wnt pathway components during prenatal mouse lung development using whole-mount in situ hybridization...
A machine learning approach to determine the elastic properties of printed fiber-reinforced polymers
This work focuses on the simultaneous determination of elastic constants and fiber orientation state for a short fiber-reinforced polymer composite by performing minimum experimental tests. We introduce methodology that enables inverse in-situ properties tensile tests at coupon level. demonstrate approach extrusion deposition additive manufacturing (EDAM) process to illustrate one application m...
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