Scavenger receptor (SR)-BI mediates the selective uptake of high density lipoprotein (HDL) cholesteryl esters and the efflux of free cholesterol. In Chinese hamster ovary (CHO) cells, SR-BI is predominantly associated with caveolae which we have recently demonstrated are the initial loci for membrane transfer of HDL cholesteryl esters. Because cholesterol accumulation in macrophages is a critic...

We assessed the clinical and pharmacological profile of the orally active V(1) vascular vasopressin (AVP) receptor nonpeptide antagonist SR49059 (SR) during the osmotic stimulation of AVP release in hypertensive patients. In a double-blind crossover-versus-placebo study, 24 untreated stage I or II essential hypertensive patients (12 whites and 12 blacks) received a single 300 mg oral dose of SR...

Here we determined the (90)Sr concentrations in the teeth of cattle abandoned in the evacuation area of the Fukushima-Daiichi Nuclear Power Plant (FNPP) accident. (90)Sr activity concentrations in the teeth varied from 6-831 mBq (g Ca)(-1) and exhibited a positive relationship with the degree of radioactive contamination that the cattle experienced. Even within an individual animal, the specifi...

The pyrolysis of two types of tobacco residue was carried out at different pyrolysis temperatures between 300 and 600 °C and a residence time of 1 h in a nitrogen atmosphere. The effect of pyrolysis temperature on the product distributions was investigated and the composition of the bio-oils identified. The variation in product distribution depended on both the temperature and the type of tobac...

OBJECTIVES The drug K201 (JTV-519) increases inotropy and suppresses arrhythmias in failing hearts, but the effects of K201 on normal hearts is unknown. METHODS The effect of K201 on excitation-contraction (E-C) coupling in normal myocardium was studied by using voltage-clamp and intracellular Ca(2+) measurements in intact cells. Sarcoplasmic reticulum (SR) function was assessed using permeab...

Based on clinical trials showing the efficacy to reduce vertebral and non-vertebral fractures, strontium ranelate (SrR) has been approved in several countries for the treatment of postmenopausal osteoporosis. Hence, it is of special clinical interest to elucidate how the Sr uptake is influenced by dietary Ca deficiency as well as by the formula of Sr administration, SrR versus strontium chlorid...

The Mauritanian Tasiast unit in the Southwestern Reguibat Archean Shield (North of West African craton = WAC) consists mainly gneiss dated between 3.07 and 2.91 Ga. We present new field petrographic observations combined with whole-rock geochemical data on gneisses to understand their petrogenesis, tectonic setting, evolution continental crust WAC. These provide firm evidence two distinct ortho...

Rationale: Mutations of the ryanodine receptor (RyR) cause catecholaminergic polymorphic ventricular tachycardia (CPVT). These mutations predispose to the generation of Ca waves and delayed afterdepolarizations during adrenergic stimulation. Ca waves occur when either sarcoplasmic reticulum (SR) Ca content is elevated above a threshold or the threshold is decreased. Which of these occurs in car...

The effects of E2 on the high-density lipoprotein receptor (HDL-R) scavenger receptor class B type I (SR-BI) gene were examined. Four putative estrogen response element half-site motifs (ERE(1/2)) (-2176, -1726, -1622, and -1211, designated ERE(1/2)-1, 2, 3, and 4, respectively) were identified in the HDL-R SR-BI promoter. Transfection studies and mutation analysis demonstrated that E2 signific...

Cardiac sarcoplasmic reticulum (SR) has several chloride (Cl-) channels, which may neutralize the charge across the SR membrane generated by Ca 2+ movement. We recently reported a novel 116picosiemen Clchannel that is activated by protein kinase A-dependent phosphorylation in cardiac SR. This Clchannel may serve as a target protein in the receptor-dependent regulation of cardiac excitation-cont...