From the Hematology-Oncology Division, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 021 I1, the *Department of Pathology, New York University, New York, 10016, the *Department of Biochemistry and Pharmacology, Tufts University School of Medicine, and the ~Departments of Microbiology, Human Genetics and Development, and Neurology,...

This nested case-control study examined relationships between MDR1, CYP2B6, and CYP3A4 variants and hepatotoxicity during antiretroviral therapy with either efavirenz- or nevirapine-containing regimens. Decreased risk of hepatotoxicity was associated with MDR1 3435C-->T (odds ratio, 0.254; P=.021). An interaction between MDR1 and hepatitis B surface antigen status predicted risk with 82% accura...

From the Laboratory of Clinical Znuestigation, National Institute of Allergy and Infectious Diseases, National Znstitutes of Health, Bethesda, Maryland 20205, Department of Immunology, Faculty of Medicine, Technion-lsrael Institute of Technology, P.O.B. 9649, Haifa, Israel, and Connective Tissue-Aging Research Laboratory, Veterans Administration Outpatient Clinic, Boston, Massachusetts 02108, a...

In this work, a method for quantification of heavy metals Inductively Coupled Plasma Sector Field Mass Spectrometry (ICP-SFMS) in soil samples of El Bierzo district (Spain) has been optimized and validated. Optimization was carried out for elements: Cr, Mn, Co, Ni, Cu, Zn, Se, As, Cd, Hg, Pb and U. Validation of the method was performed with Certified and Standard Reference Materials (CRMs and ...

T. Karuppanapandian1*, T. Karuppudurai2, P. B. Sinha1, A. M. K. Haniya3 and K. Manoharan1 1Department of Plant Sciences/2Department of Animal Behaviour and Physiology, Centre of Potential in Genomic Sciences, School of Biological Sciences, Madurai Kamaraj University, Madurai-625 021, India 3Department of Biotechnology, Srimad Andavan Arts & Science College, Thiruvanaikoil, Tiruchirappalli-620 0...

I investigate RDefforts for process innovation in a monopoly with uncertain demand. Two different models are proposed, where either (i) the reservation price is affected by an additive shock and the marginal production cost is increasing, or (ii) a multiplicative shock on the slope of demand combines with a flat marginal production cost. In either case, price-setting behaviour generates a large...

OBJECTIVE This study examined the effect of self-efficacy on glycemic control, self-care behaviors, and quality of life in low-income, minority adults with diabetes. METHODS Data on 378 participants were examined. Multiple linear regression assessed associations between self-efficacy, hemoglobin A1c, medication adherence, diabetes knowledge, self-care behaviors and quality of life. RESULTS ...

The Expanded Disability Status Scale (EDSS) has been the most widely used measure of disability in multiple sclerosis clinical trials. Although EDSS has the advantage of familiarity with respect to recent proposals, yet is difficult to use consistently between evaluators. AEDSS (Automatic EDSS) is a computerized system designed to overcome this problem. It constrains the neurologist to follow p...