The present study reports on the detailed toxicological and chemotherapeutic evaluation of antituberculosis drug loaded nanoparticles in mice. A single oral dose administration of poly(lactide-co-glycolide) (PLG, a synthetic polymer) nanoparticles containing rifampicin+isoniazid+pyrazinamide+ethambutol could maintain drug levels in various tissues for 9-10 days and did not elicit any adverse re...

The accumulation of fluoroquinolones in peripheral leukocytes is well established for several members of this family of drugs. This study documented accumulation of enrofloxacin and its active metabolite, ciprofloxacin, in canine peripheral leukocytes after oral administration at 7.5, 10, or 20 mg/kg, doses that are within the currently approved label of Baytril (Bayer Corporation Animal Health...

The purpose of this study was to determine the growth cocoa seedlings on Ultisol soil treated with cow dung compost. This research conducted in piyo garden, Batanghar University, Jambi Campus II. environmental design used a completely randomized (CRD) and treatment compost which consisted 4 treatments: K0 = no (control), K1 100 gr/polybag dung, K2 150 K3 200 gr/poly bag dung. Observational data...

The generation of reactive oxygen species (ROS) and lipid peroxidation has been considered to play an important role in the pathogenesis of chronic fluoride toxicity. In the present study, the protective effects of aqueous and ethanolic extracts of tamarind leaf on fluoride induced oxidative stress in liver, kidney, heart and blood were studied. A total number of 36 female healthy albino rats w...

In this work, a novel electrochemical aptasensor was developed for sensitive and selective detection of myoglobin based on meso-tetra (4-carboxyphenyl) porphyrin-functionalized graphene-conjugated gold nanoparticles (TCPP-Gr/AuNPs). Due to its good electric conductivity, large specific surface area, and excellent mechanical properties, TCPP-Gr/AuNPs can act as an enhanced material for the elect...

BACKGROUND Golden Rice (GR) has been genetically engineered to be rich in β-carotene for use as a source of vitamin A. OBJECTIVE The objective was to compare the vitamin A value of β-carotene in GR and in spinach with that of pure β-carotene in oil when consumed by children. DESIGN Children (n = 68; age 6-8 y) were randomly assigned to consume GR or spinach (both grown in a nutrient solutio...

A nanocomposite electrode of graphene (Gr) and zinc oxide (ZnO) nanoparticles was fabricated to study the electrochemical oxidation behavior an anti-inflammatory drug, i.e., cetirizine (CET). The voltametric response CET for bare CPE, Gr/CPE, ZnO/CPE, ZnO-Gr studied. modifier materials were characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), powde...

objective: breast cancer is the second leading cause of cancer death in women. cisplatin is a traditional cancer drug commonly used in chemotherapy for killing cancer cells. modulation at the mrna levels of apoptotic related genes often correlate with the sensitivity of various types of cancer cells to chemotherapeutic agents. nanoparticulate drug delivery systems are being developed to effecti...

Let n,k,r and t be positive integers, and let [n] = {1,2, . . . ,n}. A family G ⊂ 2[n] is called r-wise t-intersecting if |G1∩·· ·∩Gr| ≥ t holds for all G1, . . . ,Gr ∈ G . Let us define a typical r-wise t-intersecting family Gi(n,r, t) and its k-uniform subfamily Fi(n,k,r, t), where 0 ≤ i ≤ ⌊n−t r ⌋, as follows: Gi(n,r, t) = {G ⊂ [n] : |G∩ [t + ri]| ≥ t +(r−1)i}, Fi(n,k,r, t) = Gi(n,r, t)∩ ([n...