Aaltosalmi, Urpo Fluid flow in porous media with the lattice-Boltzmann method Jyväskylä: University of Jyväskylä, 2005, 158 p. (Research report/Department of Physics, University of Jyväskylä, ISSN 0075-465X; 3/2005) ISBN 951-39-2222-7 Diss. The lattice-Boltzmann method has recently become a useful approach for computational fluid dynamics. Simple implementation of boundary conditions together w...

When complexity theory is studied over an arbitrary unordered eld K, the classical theory is recaptured with K = Z2. The fundamental result that the Hilbert Nullstellensatz as a decision problem is NP-complete overK allows us to reformulate and investigate complexity questions within an algebraic framework and to develop transfer principles for complexity theory. Here we show that over algebrai...

BACKGROUND Patients with refractory or relapsed haematological malignancies have few treatment options and short survival times. Identification of effective therapies with genomic-based precision medicine is hampered by intratumour heterogeneity and incomplete understanding of the contribution of various mutations within specific cancer phenotypes. Ex-vivo drug-response profiling in patient bio...

Background: To facilitate earlier diagnosis of spondyloarthritis (SpA), we have previously cross-culturally adapted a self-administered screening questionnaire. Objectives: We aimed to improve the sensitivity this questionnaire as tool by comparing various scoring methods. Methods: Subjects newly referred rheumatology clinic before seeing rheumatologist. Identification axial SpA using original ...

BACKGROUND Concerns have been expressed about asthma overdiagnosis. The UK National Institute of Health and Care Excellence (NICE) proposed a new diagnostic algorithm applying four lung function measures sequentially (ratio of forced expiratory volume in 1 s [FEV1] to forced vital capacity [FVC] <70%, bronchodilator reversibility ≥12%, fractional exhaled nitric oxide [FeNO] ≥35 parts per billio...

The role of p110d PI3K in lymphoid cells has been studied extensively, showing its importance in immune cell differentiation, activation and development. Altered T cell localization in p110d-deficient mouse spleen suggested a role for p110d in non-hematopoietic stromal cells, which maintain hematopoietic cell segregation. We tested this hypothesis using p110d mouse bone marrow to reconstitute l...