An automated system was developed to acquire three-dimensional information from metallurgical and biological specimens. The system is based on consecutive precision machining and crosssectional image recording. In the system, face milling by a single crystal diamond tool is used for high precision machining, and an optical microscope is used for cross-sectional image recording. The system enabl...

We propose to measure the cross section, Rlt, and Alt for the O(e; ep) reaction with higher precision and to much higher missing momentum and missing energy than in E89-003. We will perform this measurement at the same energy and momentum transfer (Q = 0:8 (GeV/c) and ! = 0:445 GeV). This experiment will take advantage of the Hall A high-precision spectrometers and the self-normalizing waterfal...

The trace inverse function Tr(λx−1) over the finite field F2n is a class of very important Boolean functions and has be used in many stream ciphers, for example, SFINKS, RAKAPOSHI, the simple counter stream cipher presented by W. Si and C.S. Ding, etc. In order to evaluate the security of those algorithms in assistance to (fast) algebraic attacks, it is essential to algebraic properties of Tr(λ...

We develop a special-purpose hypervisor called TrustVisor that facilitates the execution of security-sensitive code in isolation from commodity OSes and applications. TrustVisor provides code and execution integrity as well as data secrecy and integrity for protected code, even in the presence of a compromised OS. These strong properties can be attested to a remote verifier. TrustVisor only add...

Introduction Mutations in the gene encoding NLRP3 cause a spectrum of autoinflammatory diseases known as the cryopyrinassociated periodic syndromes (CAPS). NLRP3 is a key component of one of several distinct cytoplasmic multiprotein complexes (inflammasomes) that mediate the maturation of the proinflammatory cytokine interleukin1b (IL-1b) by activating caspase-1. Although several models for inf...

LLE Review, Volume 100 257 Introduction Large, high-power laser systems are currently under construction; such systems include the National Ignition Facility (NIF) at Lawrence Livermore National Laboratory (LLNL),1 the LMJ laser at CEA in France, and the OMEGA EP at LLE.2 These new lasers will require large amounts of neodymium phosphate laser glass, which is known to be sensitive to water.3 Wh...

0 d 1 eceived October 13, 003; revised and ccepted November 14, 003. eprint requests: Glenn D. raunstein, M.D., epartment of Medicine, laza Level, Room 2119, edars-Sinai Medical enter, 8700 Beverly Blvd., os Angeles, CA 90048 FAX: 310-423-0437; Eail: [email protected]). Glenn D. Braunstein, M.D., s a Principal Investigator nd a consultant for tudies conducted by rocter & Gamble harmaceuticals...

Patients have responded well to the multi-targeted tyrosine kinase inhibitor (TKI) Sunitinib in the clinic. But the severe toxic side effects associated with Sunitinib limit its therapeutic index. To improve the therapeutic index of Sunitinib, a prodrug strategy was employed to modify Sunitinib. The inactive prodrug AST-003 can be converted to Sunitinib in vitro and in vivo. Compared with Sunit...