The aim of the present study was to investigate the effects of the mammalian target of rapamycin (mTOR) inhibitor, RAD001, on the growth of human endometrial cancer cells. The effects of RAD001 on human endometrial cancer Ishikawa and HEC-1A cell proliferation were determined by MTT assay. Green fluorescent protein microtubule-associated protein 1 light chain 3α (GFP-LC3) protein aggregates wer...

The Krüppel-like factor 4 (KLF4) gene is related to various biological processes including stem cell reprogramming and tumorigenesis. In this study, we identified and characterized a non-coding transcript of KLF4, which was designated KLF4‑003, in human liver tissue samples. KLF4‑003 was identified in a number of cell lines by reverse transcription PCR and DNA sequencing. Its expression levels ...

Background: D-003 is a mixture of long-chain aliphatic primary acids purified from sugar cane wax with cholesterol-lowering and preventive effects on lipoprotein lipid peroxidation (LP) proven in experimental and clinical studies. Objectives: To investigate if D-003 favourably modifies LP markers on older individuals. Methods: This double-blinded, randomized, placebo-controlled study investigat...

We present crowdsourced collection of error annotations for transcriptions of spoken learner English. Our emphasis in data collection is on fluency corrections, a more complete correction than has traditionally been aimed for in grammatical error correction research (GEC). Fluency corrections require improvements to the text, taking discourse and utterance level semantics into account: the resu...

abstract one of the techniques that has been used in different areas of sciences, and probably would be able to simulate complicated process of rainfall-run off is artificial neural network (ann). the purpose of this research is to evaluate the applicability of ann in rainfall- run off simulation and the comparison of the results to those produced by hec-hms model in azam river basin of herat i...

Rapid and reliable flood information is crucial for minimizing post-event catastrophes in the complex river basins of world. The Chenab River basin one world, facing adverse hydrometeorological conditions with unpredictable hydrologic response. Resultantly, many vicinities along undergo destructive inundation, resulting huge life economic losses. In this study, Hydrologic Engineering Centre–Hyd...

Towards the end of the 1980s, the issue of whether IS case research was rigorously conducted was first raised. Benbasat et al. (1987) and Lee (1989) formulated some key recommendations on how to conduct high quality case study research in our field. Since then, qualitative research, in general, and case research in particular, has evolved and grown considerably. For example, researchers from se...

ATLAS has chosen for its Hadronic End-Cap Calorimeter (HEC) the copper-liquid argon sampling technique with flat plate geometry and GaAs pre-amplifiers in the argon. The contruction of the calorimeter is now approaching completion. Results of production quality checks are reported and their anticipated impact on calorimeter performance discussed. Selected results, such as linearity, electron an...