introduction compartmental analysis allows the mathematical separation of tissues and organs to determine activity concentration in each point of interest. biodistribution studies on humans are costly and complicated, whereas such assessments can be easily performed on rodents. in this study, we aimed to develop a pharmacokinetic model of 153sm-maltolate complex as a novel therapeutic agent and...

background:ecstasy, mainly composed of 3,4-methylenedioxymethamphetamine (mdma), is one of the most popular addictive synthetic drugs. this study was aimed to investigate the amount of mdma in the ecstasy tablets seized in west azerbaijan province, northwest iran and also to assess the relationship between the physicochemical and morphological characteristics of the tablets. methods: mdma conte...

normal 0 false false false en-us x-none ar-sa carotid body tumor (cbt) is paraganglioma and mainly found in the carotid bifurcation. the manifestations of the tumor are variable; in most cases, it presents as a non-symptomatic slow-growing mass, rarely compression of carotid body induces bradycardia and hypotension and repeated syncope, prolonged syncope can cause convulsion. convulsive syncope...

parkinson’s disease is one of the most common neurodegenerative disorders.  there are many documents about the effects of oxidative stress in parkinson’s disease etiology. angiotensin ii activates nadph dependent oxidases and causes superoxides formation.  peganum harmala l. extract, which has angiotensin converting enzyme (ace) inhibitory effect, is considered to evaluate oxidative stress inhi...

accurate estimation of reference evapotranspiration plays a key role in water resources management and irrigation scheduling. the fao penman-monteith (f-p-m) is a reference method for calculation of evapotranspiration that needs temperature, humidity, wind speed and solar radiation. in many stations, it is not an easy task to measure the whole weather variables. thus, in this situation, one mus...

the aim of this study was to evaluate germination of different sesame genotypes on response to temperature. heat and cold tolerance indexes were determined using cardinal temperatures and evaluations of genotypes were conducted to tolerate high or low temperatures using determined indexes. in order to, germination tests were conducted in fixed temperatures incubators with 10, 15, 20, 25, 30, 35...

objective(s): 3, 4-methylenedioxymethamphetamine (mdma) one of the methamphetamine derivatives that affect the reproductive system, has not been well understood. many young people are consumers of drugs such as mdma that can affect their reproductive capability. apoptosis is the main mechanism for male infertility. pentoxifylline (ptx) increases camp intracellularly and reduces tumor necrosis f...

background: it has been proposed that oxidative stress plays an important role in male infertility. the aims of this study were to compare seminal plasma levels of 15-f2t-isoprostane (8-iso-pgf2?), malondialdehyde (mda), and total (sum of free and bound) homocysteine (thcy) in normozoospermic vs. asthenozoospermic men, and to examine the relationships between thcy and lipid peroxidation product...

a simple and efficient method for synthesis of tetrahydropyrimido[4,5-b]quinoline derivatives via three component reaction of aromatic aldehydes, dimedone and 6-amino uracil derivatives using a catalytic amount of sulfonic acid functionalized nanoporous silica (sba-15-pr-so3h) is described. the advantages of this method are easy and clean work-up, high yield, mild reaction condition, reusable c...

introduction: malignant astrocytic gliomas are the most common and lethal brain malignancies due to their refractory to the current therapies. nowadays, molecular targeted therapy has attracted great attention in treatment of glioma. connexin 43 (cx43) and micro ribonucleic acid- 21(mir-21) are among molecules that are involved in glioma development and progression. these molecules showed poten...