نتایج جستجو برای: گیرنده ccr5

تعداد نتایج: 10087  

Journal: :Blood 2002
Anja Mueller Eamonn Kelly Philip G Strange

M-tropic human immunodeficiency virus (HIV-1) strains enter the cell after interaction with their receptors, CD4 and the G-protein-coupled chemokine receptor CCR5. The number of cell surface CCR5 molecules is thought to be important in determining the infection rate for HIV. Cell surface CCR5 is dependent on the rate of receptor internalization and recycling. Internalization of G-protein-couple...

Journal: :Journal of immunology 2008
Gabriel T Schnickel Sam Bastani George R Hsieh Ali Shefizadeh Rubina Bhatia Michael C Fishbein John Belperio Abbas Ardehali

Chemokine-chemokine receptor interactions orchestrate mononuclear cells recruitment to the allograft, leading to acute and chronic rejection. Despite biologic redundancy, several experimental studies have demonstrated the importance of CXCR3 and CCR5 in acute rejection of allografts. In these studies, deficiency or blockade of CXCR3 or CCR5 led to prolongation of allograft survival, yet allogra...

Journal: :The Journal of clinical investigation 2009
Ekihiro Seki Samuele De Minicis Geum-Youn Gwak Johannes Kluwe Sayaka Inokuchi Christina A Bursill Josep M Llovet David A Brenner Robert F Schwabe

Hepatic fibrosis develops as a response to chronic liver injury and almost exclusively occurs in a proinflammatory environment. However, the role of inflammatory mediators in fibrogenic responses of the liver is only poorly understood. We therefore investigated the role of CC chemokines and their receptors in hepatic fibrogenesis. The CC chemokines MIP-1alpha, MIP-1beta, and RANTES and their re...

2005
V Pokorny A Harrison J Highton L McLean

Background: Ligands of chemokine receptor CCR5, including MIP-1a, MIP-1b, and RANTES, have been implicated in rheumatoid arthritis. Objective: To test whether CCR5 d32 polymorphism has a negative association with rheumatoid arthritis in a New Zealand cohort. Methods: 516 white patients with rheumatoid arthritis and 985 healthy controls were investigated by PCR amplification of the region flanki...

Journal: :PLoS ONE 2007
Bonnie R. Pedersen Deborah Kamwendo Melinda Blood Victor Mwapasa Malcolm Molyneux Kari North Stephen J. Rogerson Peter Zimmerman Steven R. Meshnick

BACKGROUND CCR5 and CCR2 gene polymorphisms (SNPs) have been associated with protection against HIV transmission in adults and with delayed progression to AIDS. The CCR5 Delta32 deletion and SNP -2459G are associated with reduced expression of the CCR5 protein. METHODOLOGY/PRINCIPAL FINDINGS We investigated the association between infant CCR2/CCR5 diplotype and HIV mother to child transmissio...

Journal: :Journal of the American Society of Nephrology : JASN 2009
Friso L H Muntinghe Marion Verduijn Mike W Zuurman Diana C Grootendorst Juan Jesus Carrero Abdul Rashid Qureshi Karin Luttropp Louise Nordfors Bengt Lindholm Vincent Brandenburg Martin Schalling Peter Stenvinkel Elisabeth W Boeschoten Raymond T Krediet Gerjan Navis Friedo W Dekker

The CC-chemokine receptor 5 (CCR5) is a receptor for various proinflammatory chemokines, and a deletion variant of the CCR5 gene (CCR5 Delta 32) leads to deficiency of the receptor. We hypothesized that CCR5 Delta 32 modulates inflammation-driven mortality in patients with ESRD. We studied the interaction between CCR5 genotype and levels of high-sensitivity C-reactive protein (hsCRP) in 603 inc...

Journal: :Blood 2011
Heather A Pilch-Cooper Scott F Sieg Thomas J Hope Ann Koons Jean-Michel Escola Robin Offord Ronald S Veazey Donald E Mosier Brian Clagett Kathy Medvik Julie K Jadlowsky Mark R Chance Janna G Kiselar James A Hoxie Ronald G Collman Nadeene E Riddick Valentina Mercanti Oliver Hartley Michael M Lederman

CC Chemokine Receptor 5 (CCR5) is an important mediator of chemotaxis and the primary coreceptor for HIV-1. A recent report by other researchers suggested that primary T cells harbor pools of intracellular CCR5. With the use of a series of complementary techniques to measure CCR5 expression (antibody labeling, Western blot, quantitative reverse transcription polymerase chain reaction), we estab...

Journal: :Journal of virology 2003
Fotini Tsamis Svetlana Gavrilov Francis Kajumo Christoph Seibert Shawn Kuhmann Tom Ketas Alexandra Trkola Anadan Palani John W Clader Jayaram R Tagat Stuart McCombie Bahige Baroudy John P Moore Thomas P Sakmar Tatjana Dragic

Human immunodeficiency virus type 1 (HIV-1) entry is mediated by the consecutive interaction of the envelope glycoprotein gp120 with CD4 and a coreceptor such as CCR5 or CXCR4. The CCR5 coreceptor is used by the most commonly transmitted HIV-1 strains that often persist throughout the course of infection. Compounds targeting CCR5-mediated entry are a novel class of drugs being developed to trea...

Journal: :Antimicrobial agents and chemotherapy 2003
Cristina Pastore Gastón R Picchio Francesco Galimi Richard Fish Oliver Hartley Robin E Offord Donald E Mosier

C-C chemokine receptor 5 (CCR5) is the primary coreceptor for human immunodeficiency virus type 1 (HIV-1) infection. Native chemokines that bind to CCR5 inhibit HIV-1 infection, albeit weakly, but chemically modified chemokines inhibit infection more efficiently. We have investigated the inhibitory mechanism of three N-terminally modified RANTES variants (AOP-, NNY-, and PSC-RANTES) with the MT...

Journal: :Journal of virology 1999
N Dejucq G Simmons P R Clapham

Human immunodeficiency virus type 1 (HIV-1) non-syncytium-inducing (NSI) strains predominantly use the chemokine receptor CCR5, while syncytium-inducing (SI) strains use CXCR4. In vitro, SI isolates infect and replicate in a range of CD4(+) CXCR4(+) T-cell lines, whereas NSI isolates usually do not. Here we describe three NSI strains that are able to infect two CD4(+) T-cell lines, Molt4 and Su...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید