Corticocortical interactions between the primary motor cortex, the ventral premotor cortex and posterior parietal motor areas, such as the anterior and caudal intraparietal sulcus, are relevant for skilled voluntary hand function. It remains unclear to what extent these brain regions and their interactions also contribute to basic motor functions after stroke. We hypothesized that white matter ...

Prediction of clinical efficacy, toxicity, and drug-drug interactions may be improved by accounting for the intracellular unbound drug concentration (Cunbound) in vitro and in vivo. Furthermore, subcellular drug distribution may aid in predicting efficacy, toxicity, and risk assessment. The present study was designed to quantify the intracellular Cunbound and subcellular localization of drugs i...

Institute of Environmental Systems Barbarastraße 12, D-49076 Osnabrueck, Ge 2 38 64 3668 Department of Biology/Chemistry, Divisio Barbarastraße 13, D-49076 Osnabrueck, Ge Environmental Mineralogy, Institute for Ap Darmstadt, Schnittspahnstr. 9, D-64287 Da † Electronic supplementary informa 10.1039/c3em00214d ‡ Present address: Water, Environment an Recherches Géologiques et Minières (BRG 36009,...

هدف: کارآفرینی یکی از عوامل کلیدی در توسعه اقتصادی و شاخص اساسی جوامع روبه‌رشد است. آنچه که کارآفرین را به آغاز فعالیت ترغیب می‌کند، انگیزه فرایند تبدیل یک فرد عادی است می‌تواند فرصت‌هایی ایجاد کند حداکثر رساندن ثروت کمک کند. هدف این پژوهش شناسایی طبقه‌بندی انگیزه‌های کارآفرینان می­باشد.طراحی/ روش‌شناسی/ رویکرد: با رویکرد مرور نظام­مند استفاده ماتریس شش سلولی دو مؤلفه جهت (کشش یا فشار) منبع (اق...

During the warm dry summer and autumn of 1947 the prevalence of acute anterior poliomyelitis increased in Britain to an extent never before recorded. Cases were widespread but unevenly distributed over the country ; and some areas, notably the mountains of Wales and Scotland, showed no epidemic incidence of the disease. -The greatest number of cases occurred in August, and the curve was still h...