In this study we investigated the agewise distributions of serum IgA concentrations in 1251 type 1 and 2224 type 2 diabetic patients, and the association between serum IgA concentration and diabetic complications (retinopathy, neuropathy, nephropathy, macroangiopathy, and hypertension). The IgA concentrations of all groups of diabetic patients were significantly higher than those of the corresp...

G. Rostoker, Department of Nephrology, INSERM U 139 and Fond d’Etudes du Corps médical H. Mondor, F-94010 Créteil (France) Sir, A possible relationship of primary IgA nephropathy (IgA GN) with wheat gliadin and latent celiac disease (CD) has been suggested by the presence of high levels of circulating IgA antigliadin antibodies [5], the decrease of IgA-containing circulating immune complexes af...

Mucosal IgA is important in local immune defence. Helicobacter pylori induces a specific IgA response in antral mucosa, but its immunopathology is unknown. Interleukin-8 (IL-8) has been suggested to be important in H. pylori-induced inflammation. Current information on the relationship between H. pylori-induced IgA and mucosal inflammation is limited. To investigate possible associations betwee...

Power transformer is an essential component for the stable and reliable operation of electrical power grid. The traditional fault diagnostic methods based on dissolved gas analysis are limited due to low accuracy identification. In this study, effective diagnosis system proposed improve identification accuracy. approach combines improved genetic algorithm (IGA) with XGBoost form a hybrid networ...

This study aims to develop and validate an investigator global assessment score (IGA) for keratosis pilaris (KP), a highly prevalent, benign, follicular disorder, standardize disease assessment. To our knowledge, there is currently no scoring system KP. A composite IGA score, Keratosis Pilaris Area Index (KPAI), was created compared 0-4 defined KP known as KP-IGA. validation done determine the ...

PurposeLong-term survival after lung transplantation (LT) is hampered by the occurrence of chronic allograft dysfunction (CLAD). CLAD may manifest as bronchiolitis obliterans syndrome (BOS) or restrictive (RAS), and triggered several factors, e.g. post-transplant infections. As immunoglobulin (Ig) A crucial to ensure mucosal immunity limit airway microbial load, we explored whether IgA its epit...

IgA is the predominant immunoglobulin isotype in mucosal tissues and external secretions, playing important roles both in defense against pathogens and in maintenance of commensal microbiota. Considering the complexity of its interactions with the surrounding environment, IgA is a likely target for diversifying or positive selection. To investigate this possibility, the action of natural select...

We have previously shown that human B lymphocytes cultured in the CD40 system, composed of an anti-CD40 mAb presented by a CD32-transfected fibroblastic cell line, proliferate but do not secrete antibodies. However, the addition of particles of Staphylococcus aureus Cowan (SAC) induces B cell differentiation even in the absence of exogeneous cytokines (CD40/SAC system). Additionally, B lymphocy...

The temporal association of tonsillitis and hematuria or proteinuria in IgA nephropathy suggests that there might be a link between the physiological properties of the secondary lymphoid organ that tonsils represent and the mesangial deposition of IgA characteristic of this nephropathy. A number of clinical and ex-vivo data support this hypothesis. One of the earliest was the demonstration of t...

BACKGROUND The clinical utility of testing for antiphospholipid antibodies (aPL) of IgA isotype remains controversial. METHODOLOGY/PRINCIPAL FINDINGS To address this issue, we reasoned that if IgA aPL contribute to the clinical manifestations of the antiphospholipid syndrome, then an association with thromboembolic events should manifest in patients whose only aPL is of IgA isotype. We perfor...