The aqueous extract of Clitoria ternatea Linn leaves were screened for its antihyperglycemic activity in streptozotocin induced and glucose induced diabetic rats in doses of 100, 250 and 500 mg/kg body weight. At a dose of 100 mg/kg (bw), aqueous leaf extract did not produce significant antihyperglycemic activity, however a doses of 250 mg/kg of Clitoria Ternatea leaf extracts significantly red...

Kemball, M. L., McIver, C., Milner, R. D. G., Nourse, C. H., Schiff, D., Tiernan, J. R. (1970). Archives of Disease in Childhood, 45, 696. Neonatal hypoglycaemia in infants of diabetic mothers given sulphonylurea drugs in pregnancy. Three infants whose diabetic mothers were given chlorpropamide and one infant whose diabetic mother was given acetohexamide up to the time of delivery were studied ...

An ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry method for the simultaneous quantification of chlorpropamide, glibenclamide, gliclazide, glimepiride, metformin, nateglinide, pioglitazone, rosiglitazone, and vildagliptin in human plasma was developed and validated, using isoniazid and sulfaquinoxaline as internal standards. Following plasma protein precipit...

Medical Memoranda DCBRALmisHNAL 507 than cholestasis. Until recently there have been no clinical reports of liver damage associated with administration of paracetamol. However, Davidson and Eastham (1966) have now recorded two cases of liver necrosis ascribed to overdosage of paracetamol. Both patients had hypoglycaemia and neither survived. In addition, we know of two other unpublished cases o...

In previous studies we have reported that a) marked sensitivity to leucine hypoglycemia can be induced consistently in healthy subjects after the oral administration of sulfonylureas, compounds that are known to stimulate islet cell activity (1), b) a modest but significant hypoglycemic effect can be produced by administering leucine to healthy subjects without sulfonylurea pretreatment (1, 2),...