Cancer-associated fibroblasts (CAFs) are crucial co-mediators of breast cancer progression. Estrogen is the predominant driving force in the cyclic regulation of the mammary extracellular matrix, thus potentially affecting the tumor-associated stroma. Recently, a third estrogen receptor, estrogen (G-protein-coupled) receptor (GPER), has been reported to be expressed in breast CAFs. In this stud...

This study evaluated the influence of material combinations used in the resin coating technique (RCT) on the marginal adaptation of indirect restorations with gingival margins in enamel (EM) and cement (CM). Eighty third-molars were used. Two cavities were prepared in each tooth. The cavities were distributed into 16 groups. Cavities with EM were filled with the following material combinations:...

We characterise the probability distributions of various categories gross capital flows conditional on information contained in financial asset prices a panel emerging market economies, with focus ‘tail’ events. Our framework, based quantile regression methodology, allows for separate role push- and pull-type factors, because it is high-frequency data, can quantify likelihood different outturns...

Alterations in the composition of the gut microbiome and/or immune system function may have a role in the development of autism spectrum disorders (ASD). The current study examined the effects of prenatal and early life administration of lipopolysaccharide (LPS), a bacterial mimetic, and the short chain fatty acid, propionic acid (PPA), a metabolic fermentation product of enteric bacteria, on d...

Ferutinin is a daucane sesquiterpene with a high estrogenic activity in vitro and in vivo (Appendino et al., 2002; Zavatti et al., 2009). Recently, we demonstrated that ferutinin is able to enhance proliferation and osteogenic differentiation of human amniotic fluid stem cells (AFSCs) (Zavatti et al., 2013). Morover, the oral administration in rats of this phytoestrogen improved the bone regene...

Emerging evidence suggests that renal endothelial function may be altered in ischemia-reperfusion injury. Acute kidney injury is sexually dimorphic, and estrogen protects renal tubular function after experimental ischemic injury. This study tested the hypothesis that during ischemia-reperfusion, estrogen alters glomerular endothelial function to prevent hyperpermeability. Glomerular endothelial...

BACKGROUND Osteoporosis is associated with 17β-estradiol deficiency. The G protein-coupled receptor 30 (GPR30) is known to be an estrogen-responsive receptor, but its role in the degradation of mitochondria in osteoblasts by autophagy, or mitophagy, remains unclear. The aim of this in vitro study was to evaluate the effects of 17β-estradiol, GPR30, and its signaling pathway, on mitophagy in the...

G protein-coupled receptor (GPR) 30 is a novel estrogen receptor. Recent studies suggest that activation of the GPR30 confers rapid cardioprotection in isolated rat heart. It is unknown whether chronic activation of GPR30 is beneficial or not for heart failure. In this study we investigated the cardiac effect of sustained activation or inhibition of GPR30. Female Sprague-Dawley rats were divide...

مگس میوه زیتون، (Rossi) Bactrocera oleae حشره‌ای مونوفاژ بوده و مهمترین آفت زیتون در سرتاسر جهان بویژه کشورهای مدیترانه می‌باشد. این پژوهش به منظور مطالعه تغییرات جمعیت مراحل مختلف زندگی برخی ویژگی‌های زیست‌شناسی دو سال منطقه طارم سفلی استان قزوین انجام شد. نتایج بررسی نشان داد که حشره سفلی، سه تا پنج نسل دارد. زمستان را صورت حشرات کامل پناهگاه‌های ندرت شفیره زیر بقایای گیاهی خاک‌های نرم باغ‌ها...

ABSTRACT We examine how investment professionals assess the usefulness of financial accounting information depending on their acquisition objectives and preparers' earnings management incentives. conduct a survey experiment based face-to-face interviews with document two main results. First, we find that, compared assigned firm valuation objective, those managerial performance evaluation object...