Cell division cycle protein 45 (Cdc45) is required for DNA synthesis during genome duplication, as a component of the Cdc45-MCM-GINS (CMG) helicase. Despite its essential biological function, its biochemical role in DNA replication has remained elusive. Here we report the 2.1-Å crystal structure of human Cdc45, which confirms its evolutionary link with the bacterial RecJ nuclease and reveals se...

Article history: Received 9 November 2015 Received in revised form 18 April 2016 Accepted 19 April 2016 Available online 26 April 2016 An attitude tracking controller is developed for control moment gyroscope (CMG)-actuated satellites, which is shown to achieve accurate attitude tracking in the presence of unmodeled external disturbance torques, parametric uncertainty, and nonlinear CMG disturb...

We report a method to introduce direct bonding between graphene platelets that enables the transformation of a multilayer chemically modified graphene (CMG) film from a "paper mache-like" structure into a stiff, high strength material. On the basis of chemical/defect manipulation and recrystallization, this technique allows wide-range engineering of mechanical properties (stiffness, strength, d...

The purpose of this work is to express emissivity in Meteosat-8/SEVIRI channels by means of linear combinations of LSE values in the thermal bands of MODIS sensor. Then, the developed linear models are applied to MODIS11C3 monthly CMG LST product in order to obtain LSE estimations for SEVIRI channels within Meteosat-8 disk. PALAVRAS-CHAVE: Emissivity; Meteosat-8; MODIS. RESUMO. O objetivo deste...

The eukaryotic replisome is a molecular machine that coordinates the Cdc45-MCM-GINS (CMG) replicative DNA helicase with DNA polymerases α, δ, and ε and other proteins to copy the leading- and lagging-strand templates at rates between 1 and 2 kb min-1. We have now reconstituted this sophisticated machine with purified proteins, beginning with regulated CMG assembly and activation. We show that r...

Gurpreet Kaur Ranbaxy Research Labs, Gurgaon, India Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala-147002, India Tel: 919814724622 Fax +91-(0175)-3046255 Email: [email protected] Abstract The present study was designed to formulate colon release tablets of fluticasone by employing cross linked chitosan (CH) and carboxymethyl guar gum (CMG) interpolymer comp...