Bacterial superantigens (BSAgs) cause massive stimulation of the immune system and are associated with various pathologies and diseases. To address the role of antibodies in protection against BSAgs, we screened the sera of 29 human volunteers for antibodies to the SAgs staphylococcal enterotoxin A (SEA), SEB, SEC1, and toxic shock syndrome toxin 1 (TSST-1). Although all volunteers had detectab...

Tst, the gene for toxic shock syndrome toxin-1 (TSST-1), is part of a 15.2 kb genetic element in Staphylococcus aureus that is absent in TSST-1-negative strains. The prototype, in RN4282, is flanked by a 17 nucleotide direct repeat and contains genes for a second possible superantigen toxin, a Dichelobacter nodosus VapE homologue and a putative integrase. It is readily transferred to a recA rec...

BACKGROUND The underlying mechanism of atopic dermatitis (AD) exacerbated by Staphylococcus aureus has not been established. However, we demonstrated recently that the majority of S. aureus strains colonized in the skin of Korean AD patients carried genes encoding staphylococcal enterotoxin A (SEA) and/or toxic shock syndrome toxin-1 (TSST-1). OBJECTIVE To clarify the role of staphylococcal s...

Different synthetic DNA nucleotide sequences were evaluated as gene probes for the specific detection and differentiation of Staphylococcus aureus strains encoding enterotoxins A (SEA), B (SEB), and C (SEC) and toxic shock syndrome toxin 1 (TSST-1). Identification of sequences unique to each toxin, based on knowledge of their nucleotide sequences, led to preparation of the specific 18-base olig...

OBJECTIVE To test whether a brief mindfulness meditation training intervention buffers self-reported psychological and neuroendocrine responses to the Trier Social Stress Test (TSST) in young adult volunteers. A second objective evaluates whether pre-existing levels of dispositional mindfulness moderate the effects of brief mindfulness meditation training on stress reactivity. METHODS Sixty-s...

Since the 1990s there have only been a few studies with human subjects that focused on the underlying mechanisms associated with acute psychological stress exposure and even less have been conducted with children. Based on the idea that it is possible to elicit and measure behavioral and physiological patterns in response to stressors in a short period of time, the Trier Social Stress Test (TSS...

In the emotion regulation process more than one strategy is often used, though studies continue to rely on manipulation of alone. This study compares effects Combined Cognitive Reappraisal (CCR: acceptance and reappraise via perspective-taking) suppression using Trier Social Stress Test (TSST). One hundred participants were randomly assigned two groups subjective, physiological, behavioural dat...

Proinflammatory cytokines mediate the toxic effects of staphylococcal exotoxins (SE). This study compared the potency of two polyphenols, green tea epigallocatechin gallate (EGCG) and red wine resveratrol (RES), in blocking the pro-inflammatory effects of staphylococcal enterotoxin B (SEB) and toxic shock syndrome 1 (TSST-1). Both EGCG and RES dose-dependently inhibited superantigen-stimulated ...

conclusions our outcomes showed elevated incidences of tsst-1 positive and mrsa strains with higher rates of antibiotic resistance. the conflict between our findings and other records may be due to differences in geographic regions. materials and methods the presence of the tsst-1 and meca genes was investigated by polymerase chain reaction (pcr) among s. aureus isolated from 197 clinical sampl...