p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells Andrei N. Mardaryev1, Michal R. Gdula1,2, Joanne L. Yarker1, Vladimir U. Emelianov3, Krzysztof Poterlowicz1, Andrey A. Sharov3, Tatyana Y. Sharova3, Julie A. Scarpa1, Boris Joffe4, Irina Solovei4, Pierre Chambon5, Vladimir A. Botchkarev1,...

زمینه و هدف: کم‌تحرکی در مقابل آن تمرین جزء عوامل مرتبط با شاخص‌های آسیب کبدی به‌شمار می‌روند. وجود این هنوز نقش بسیاری از تمرین‌های ورزشی به‌ویژه تمرینات تناوبی مقاومتی مصرف برخی مکمل‌های غذایی جمله اسپیرولینا بر ایمنی التهابی کاملاٌ شناخته نشده است؛ بنابراین هدف پژوهش تعیین اثر هشت هفته مکمل‌دهی هوازی فعالیت بافت کبد بیان ژن CXCL1 عضلة موش‌های صحرایی نر بود.مواد روش‌ها: نیمه‌تجربی، 60 سر موش ن...

Protein ubiquitylation catalyzed by E3 ubiquitin ligases are crucial in the regulation of many cellular processes. Owing to the high throughput of mass spectrometry-based proteomics, a number of methods have been developed for the experimental determination of ubiquitylation sites, leading to a large collection of ubiquitylation data. However, there exist no resources for the exploration of E3-...

PURPOSE The purpose of this study was to evaluate the subset of limbal epithelial cells with greater nucleus-to-cytoplasm (N/C) ratio expressing high levels of p63 for their slow-cycling property, a characteristic feature of stem cells (SCs). METHODS Limbal and peripheral corneal explant cultures were pulse labeled with 5-5-bromo-2'-deoxyuridine (BrdU) for 5 days, followed by a period of 3-we...

CHARLES FRANKLIN KETTERING was born near Loudonville, Ashland County, Ohio, on August 29, 1876. He is vice-president of the General Motors Corporation and general manager of its Research Laboratories Division. Many and various honors have been bestowed on Kettering, including doctor's degrees from several universities, medals, honorary memberships in technical societies, election to the Nationa...

Ketoconazole (KET), an imidazole derivative with well-known antifungal properties, is lipophilic and practically insoluble in water, therefore its clinical use has some practical disadvantages. The aim of the present study was to investigate the influence of PAMAM-NH(2) and PAMAM-OH dendrimers generation 2 and generation 3 on the solubility and antifungal activity of KET and to design and evalu...

The usual bra-ket formalism is generalized to finite-dimensional vector spaces with indefinite metric in a simple mathematical context similar to that of the theory of general tensors where, in addition, scalar products are introduced with the help of a metric operator. The specific calculation rules are presented with all their details in a suitable intuitive notation. It is shown that the pro...

TP63 gene encodes p63, which is a major transcription factor of the epithelial system. Mutations in underlie variety autosomal dominantly-inherited ectodermal dysplasia syndromes, which, most cases, share several symptoms including cleft lip/palate. In this study, we analyzed child with certain showing hypotrichosis, oligodontia, and hypoplastic nails, but did not have We identified novel heter...