We have previously shown that autonomous replication of human chromosome fragments is stimulated by the presence of an 18 bp sequence, REE1, which exhibits transcriptional silencer activity. The REE1 sequence is partly homologous with the serum response element (SRE) required for expression of the human c- fos gene. Here we have examined interaction of REE1 with human nuclear proteins using a g...

although it is well established that women are more likely to sustain certain connective tissue injuries than men during physical activities, this difference between males and females is not clear. gelatinases degrade components of tendon tissue. thus, in this research, the effects of gender on serum gelatinases (mmp-2 and mmp-9) at rest and in response to acute endurance exercise were investig...

Normal serum contains a lymphocyte response depressive factor and this is more active against the lymphocytes of the blood from which the serum was obtained than against lymphocytes from a different normal blood. The suppressive factor is thus "tailor-made" to its own lymphocytes though cross-reactivity with other lymphocytes does occur. The significance of this is discussed. The suppressive fa...

The parathyroid hormone-like peptide (PLP) gene is widely expressed in normal and neoplastic tissues. Previous studies have demonstrated that PLP gene expression is regulated by serum and cycloheximide, features common to the regulation of a number of different early response genes. We now report that PLP mRNA transcripts are induced within 5 min of exposure of rat keratinocytes to serum, retur...