Pure erythroid leukemia (PEL) is rare hematopoietic neoplasm characterized by uncontrolled proliferation of immature erythroid precursors - mainly abnormal proery-throblasts - comprising at least 80% of bone marrow cells. In this paper, I present a case of 48 years old patient, who presented with pancytopenia and circulating erythroblast in peripheral blood after long history of alcohol abuse. ...

Reports on PEL chapter activities and meetings worldwide.

BACKGROUND Pleural manometry can predict the presence of trapped lung and guide large-volume thoracentesis. The current technique for pleural manometry transduces pressure from the needle or intercostal catheter, necessitating intermittent cessation of fluid drainage at the time of pressure recordings. OBJECTIVES To develop and validate a technique for performing continuous pleural manometry,...

BACKGROUND It is widely accepted that the development of atherosclerosis starts at an early age. However, there are very few studies evaluating the prevalence of the common clinical and behavioral cardiovascular disease (CVD) risk factors among children, especially in developing countries. The aim of the present cross-sectional survey was to evaluate the distribution of blood lipid profile and ...

PURPOSE Phosphatidylinositol 3'-kinase (PI3'-kinase) can be activated by the K1 protein of Kaposi sarcoma-associated herpes virus (KSHV). However, the role of PI3'-kinase in KSHV-associated primary effusion lymphoma (PEL) is not known. To assess this, we studied survival and apoptosis in PEL cell lines following inhibition of PI3'-kinase. EXPERIMENTAL DESIGN Constitutive activation of several...

Human herpesvirus-8, or KSHV, was discovered in 1994 and is the causative agent of all forms of Kaposi’s sarcoma (KS). It is also associated with two lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The KSHV viral chemokine receptor, vGPCR, is a homologue of the IL8 receptors CXCR1 and CXCR2. vGPCR is considered a viral oncogene: it transforms...

Kaposi sarcoma herpesvirus (KSHV) is specifically associated with Kaposi sarcoma (KS) and 2 B cell lymphoproliferative diseases, namely primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). KS, PEL, and MCD are largely incurable and poorly understood diseases most common in HIV-infected individuals. Here, we have revealed the role of viral FLICE-inhibitory protein (vFLIP) in...

We review the current state of research on glasses, discussing the theoretical background and computational models employed to describe them. This article focuses on the use of the potential energy landscape (PEL) paradigm to account for the phenomenology of glassy systems, and the way in which it can be applied in simulations and the interpretation of their results. This article provides a bro...

The pelA and pelC genes from Erwinia chrysanthemi EC16 were sequenced and overexpressed in Escherichia coli cells. These genes and two others from the same strain that were characterized previously encode catalytically related pectate lyase proteins that are involved with the maceration and soft-rotting of plant tissue. The pel genes of strain EC16 were organized as two loosely linked clusters,...

Introduction: Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin’s lymphoma, which is characterized by serous effusion in body cavities without detectable tumor masses or lymphadenopathy. It is usually found in human herpes virus 8 (HHV8) and human immunodeficiency virus (HIV) positive patients, and tumor cells usually show a B-cell–lineage immunophenotype. Case presentation: In the ...