نتایج جستجو برای: ژن p14
تعداد نتایج: 17174 فیلتر نتایج به سال:
BACKGROUND Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis or global gene expression profiles have failed to identify mechanisms causing in vivo resistance to anthracyclines. While we previously found TP53 mutations in the L2/L3 domain...
Introduction: Retinoblastoma is the most common primary ocular malignancy in pediatric age. Knudson proposed his two-hit model, allowing the distinction of retinoblastoma in two major classes: heritable and non-heritable. Retinoblastoma was first considered to arise from a well known mutation in the RB1 tumor-suppressor gene (chromosome 13q14). Currently, evidence supports that biallelic inacti...
Abstract The Aceh patchouli plant ( Pogostemon cablin . Benth) is a plantation that produces essential oils with great potential, known as oil. use of in vitro culture techniques on plants needs to be developed meet the seeds. This study aimed analyze effect growth regulators (PGRs) cytokinins 6-Benzyl Amino Purine (BAP) and Thidiazuron (TDZ) auxin 1-Naphthaleneacetic Acid (NAA) organogenesis a...
English We show that the ring Z p 14; 1=2] is Euclidean and that this ring admits a totally multiplicative Euclidean function. This example is interesting because it is related to the ring Z p 14] which is conjectured to be Euclidean but for which a proof is lacking. French Nous montrons que l'anneau Z p 14; 1=2] est euclidien et que cet an-neau admet une fonction euclidienne totalement multipl...
Rationale The role of circulating fetal monocytes in bronchopulmonary dysplasia is not known. We utilized a humanized mouse model that supports human progenitor cell engraftment (MISTRG) to test the hypothesis prenatal monocyte programming alters early lung development and response hyperoxia. Methods Cord blood-derived from 10 infants were adoptively transferred into newborn MISTRG mice at p0 (...
سرطان مری با رتبه زیر ده مرگ و میر در بین انواع سرطانها در دنیا و رتبه ششم مرگ و میر در ایران، شیوع بالایی دارد . از آنجا که یکی از دیدگاههای مورد توجه در تشخیص سرطان، مطالعه فرآیندهای مولکولی و بیوشیمیایی سرطان است، در این پروژه تحقیقاتی به بررسی مارکرهای چندگانه ژنتیکی و بیوشیمیایی در ایجاد سرطان بافت پوششی سنگفرشی مری در مبتلایان ایرانی پرداخته شد. با توجه به وجود ارتباط تنگاتنگ بین تولید مث...
MicroRNAs (miRNA) regulate complex patterns of gene expression, and the relevance of altered miRNA expression to ovarian cancer remains to be elucidated. By comprehensively profiling expression of miRNAs and mRNAs in serous ovarian tumors and cell lines and normal ovarian surface epithelium, we identified hundreds of potential miRNA-mRNA targeting associations underlying cancer. Functional over...
The genome of Sapovirus (SaV), a causative agent of gastroenteritis in humans and swine, contains either two or three open reading frames (ORFs). Functional motifs characteristic to the 2C-like NTPase (NTPase), VPg, 3C-like protease (Pro), 3D-like RNA-dependent RNA polymerase (Pol), and capsid protein (VP1) are encoded in the ORF1 polyprotein, which is afterwards cleaved into the nonstructural ...
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