Background Modern advances in sequencing technology have enabled the census of microbial members of many natural ecosystems. Recently, attention is increasingly being paid to the microbial residents of human-made, built ecosystems, both private (homes) and public (subways, office buildings, and hospitals). Here, we report results of the characterization of the microbial ecology of a singular bu...

RATIONALE 1018 ISS is a synthetic oligonucleotide containing immunostimulatory CpG motifs. In animal studies, 1018 ISS effectively inhibited Th2-mediated lung inflammation, including eosinophil infiltration, and airway hyperresponsiveness. OBJECTIVES To evaluate whether 1018 ISS has activity in subjects with allergic asthma. METHODS Forty subjects (n = 21, 1018 ISS; n = 19, placebo) were en...

The Advanced Closed Loop System (ACLS) is currently under development by Airbus Defense and Space and is slated for launch to the International Space Station (ISS) in 2017. The addition of new hardware into an already complex system such as the ISS life support system (LSS) always poses operational risks. It is therefore important to understand the impacts ACLS will have on the existing systems...

Current conceptualisations of information systems strategy (ISS) in knowledge-based small and medium enterprises (KSMEs) suggest the utilisation of a core competencies approach. This research explores the current nature of ISS in twelve Australian SMEs in one of the most knowledge intensive industries, the biotechnology industry. An emergent model is presented and evaluated against existing lit...

The paper presents the first result on nonholonomic systems enjoying Input to State Stability (ISS) properties. Although it is known that smooth stabilizability implies ISS, the converse is not generally true. This leaves the possibility of non smoothly stabilizable systems being ISS with respect to a particular input, after an appropriate feedback transformation. This is shown to be true for t...

Input-to-state stability (ISS), integral-ISS (iISS) and their related notions of input/output stability and detectability have become a useful framework for nonlinear feedback analysis and design. In this paper, a new notion, that of constrained input-to-state stability (cISS), is presented and several characterizations of cISS are obtained. cISS, unlike ISS or iISS, is not confined to forward ...

This note discusses two integral variants of the input-to-state stability (ISS) property, which represent nonlinear generalizations of L stability, in much the same way that ISS generalizes L∞ stability. Both variants are equivalent to ISS for linear systems. For general nonlinear systems, it is shown that one of the new properties is strictly weaker than ISS, while the other one is equivalent ...