نتایج جستجو برای: ژن ctla4
تعداد نتایج: 17528 فیلتر نتایج به سال:
Objectives This multicentre retrospective study in Japan aimed to assess the retention of biological disease-modifying antirheumatic drugs and Janus kinase inhibitors (JAKi), clarify factors affecting their a real-world cohort patients with rheumatoid arthritis. Methods The included 6666 treatment courses (bDMARD-naïve or JAKi-naïve cases, 55.4%; tumour necrosis factor (TNFi) = 3577; anti-inter...
Abstract We recently demonstrated, in a mouse heart transplant model, the therapeutic effect of Enhanced Costimulation Blockade: transient combination CTLA4-Ig with JAK inhibitor Tofacitinib (Tofa). In same we also proved efficacy graft-localized delivery by means Tofa releasing hydrogel (Tofa-Hydro). this study, implemented orthotopic hind-limb VCA model to delineate any differential drug requ...
BACKGROUND Several polymorphisms of the CTLA4 gene have been associated with autoimmune diseases. The activation of induced cell death is the major event and caspase 3 represents the main protein for the apoptotic machinery, especially in lymphocytes. AIM To correlate CTLA4 polymorphisms with caspase 3 expression in peripheral blood mononuclear cells (PBMC) simulating in vitro the glucose eff...
BACKGROUND Immune system affects prognosis of various malignancies. Anti-immune pathways like PD-L1 and CTLA4 are used by the tumor to overcome immune system and they serve as immunotherapy targets. The immune microenvironment of head-and-neck squamous cell carcinoma (SCCHN) has not been sufficiently studied. PATIENTS AND METHODS 152 SCCHN were immunohistochemically studied for the expression...
Naive T cells require interleukin 4 (IL-4) to develop into IL-4-producing T cells and IL-4 blocks development of such cells into interferon gamma (IFN-gamma) producers. Prior studies in accessory cell-independent priming systems using antireceptor antibodies as agonists have demonstrated that IL-2 is also necessary for the development of IL-4-producing cells under these culture conditions. Here...
OBJECTIVES The aim of this study was to investigate the geographic distribution of β-globin gene mutations in different ethnic groups in Yunnan province. METHODS From 2004 to 2014, 1,441 subjects with hemoglobin disorders, identified by PCR-reverse dot blot and DNA sequencing, were studied according to ethnicity and geographic origin. Haplotypes were examined among 41 unrelated thalassemia ch...
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